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Information Journal Paper

Title

Lung‐ derived innate cytokines: new epigenetic targets of allergenspecific sublingual immunotherapy

Pages

  64-71

Abstract

 Objective(s): Sublingual allergen‐ specific immunotherapy is a safe and effective method for treatment of IgE‐ mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. Materials and Methods: BALB/c mice were sensitized intraperitoneally and challenged intranasally. Then, they received sublingual treatment with recombinant Che a 2 (rChe a 2), a major allergen of Chenopodium album. After SLIT, allergen‐ specific antibodies in sera, cytokine profiles of spleen cell cultures, mRNA and protein expression of lung‐ derived IL‐ 33, IL‐ 25, and TSLP (thymic stromal lymphopoietin), and histone modifications of these three genes were assessed. Results: Following Immunotherapy, systemic immune responses shifted from Th2 to Th1 profile as demonstrated by significant decrease in IgE and IL‐ 4 and substantial increase in IgG2a and IFN‐ γ . At local site, mRNA and protein levels of lung‐ derived pro‐ inflammatory cytokines IL‐ 33 and TSLP were markedly down‐ regulated following SLIT that was associated with marked enrichment of trimethylated lysine 27 of histone H3 at promoter regions of these two cytokines. Conclusion: In our study, sublingual immunotherapy with recombinant allergen effectively attenuated allergic immune responses, at least partly, by induction of distinct histone modifications at specific loci. Additionally, the lung‐ derived pro‐ allergic cytokines IL‐ 33 and TSLP could be promising mucosal candidates for either monitoring allergic conditions or therapeutic approaches.

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    APA: Copy

    Pishdadian, Abbas, VARASTEH, ABDOLREZA, GHOLAMIN, MEHRAN, ROOZBEH NASIRAIE, LEILA, Hosseinpour, Mitra, MOGHADAM, MALIHEH, & SANKIAN, MOJTABA. (2016). Lung‐ derived innate cytokines: new epigenetic targets of allergenspecific sublingual immunotherapy. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(1), 64-71. SID. https://sid.ir/paper/725712/en

    Vancouver: Copy

    Pishdadian Abbas, VARASTEH ABDOLREZA, GHOLAMIN MEHRAN, ROOZBEH NASIRAIE LEILA, Hosseinpour Mitra, MOGHADAM MALIHEH, SANKIAN MOJTABA. Lung‐ derived innate cytokines: new epigenetic targets of allergenspecific sublingual immunotherapy. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(1):64-71. Available from: https://sid.ir/paper/725712/en

    IEEE: Copy

    Abbas Pishdadian, ABDOLREZA VARASTEH, MEHRAN GHOLAMIN, LEILA ROOZBEH NASIRAIE, Mitra Hosseinpour, MALIHEH MOGHADAM, and MOJTABA SANKIAN, “Lung‐ derived innate cytokines: new epigenetic targets of allergenspecific sublingual immunotherapy,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 1, pp. 64–71, 2016, [Online]. Available: https://sid.ir/paper/725712/en

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