مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation

Pages

  29-35

Abstract

 Neurotrophins (NTs) exert various effects on neuronal system. Growing evidence indicates that NTs are involved in the pathophysiology of Neuropathic pain. However, the exact role of these proteins in modulating nociceptive signaling requires being defined. Thus, the aim of this study was to evaluate the effects of Spinal nerve ligation (SNL) on NTs activation in the lumbar dorsal root. Materials and Methods: Ten male Wistar rats were randomly assigned to two groups: tight ligation of the L5 spinal nerve (SNL: n=5) and Sham (n=5). In order to produce Neuropathic pain, the L5 spinal nerve was tightly ligated (SNL). Then, Allodynia and Hyperalgesia tests were conducted weekly. After 4 weeks, tissue samples were taken from the two groups for laboratory evaluations. Here, Real-Time PCR quantity method was used for measuring NTs gene expression levels. Results: SNL resulted in a significant weight loss in the soleus muscle (P<0. 05), mechanical Allodynia and thermal Hyperalgesia thresholds (respectively, P<0. 05; P<0. 05). Also, NGF, NT-4, NT-3, TrkA, TrkB and TrkC expression were up-regulated following Spinal nerve ligation group (respectively, P=0. 025, P=0. 013, P=0. 001, P=0. 002, P<0. 001, P=001) (respectively, 4. 7, 5. 2, 7. 5, 5. 1, 7. 2, 6. 2 folds). Conclusion: The present study provides new evidence that Neuropathic pain induced by Spinal nerve ligation probably activates NTs and Trk receptors expression in DRG. However, further studies are needed to better elucidate the role of NTs in a Neuropathic pain.

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    APA: Copy

    KAZEMI, ABDOLREZA, RAHMATI, MASOUD, ESLAMI, RASOUL, & SHEIBANI, VAHID. (2017). Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(1), 29-35. SID. https://sid.ir/paper/725757/en

    Vancouver: Copy

    KAZEMI ABDOLREZA, RAHMATI MASOUD, ESLAMI RASOUL, SHEIBANI VAHID. Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(1):29-35. Available from: https://sid.ir/paper/725757/en

    IEEE: Copy

    ABDOLREZA KAZEMI, MASOUD RAHMATI, RASOUL ESLAMI, and VAHID SHEIBANI, “Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 1, pp. 29–35, 2017, [Online]. Available: https://sid.ir/paper/725757/en

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