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Information Journal Paper

Title

Mangosteen peel extract (Garcinia mangostana L. ) as protective agent in glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis

Pages

  972-977

Abstract

 Objective(s): This study aims to evaluate the activity of mangosteen peels extract (MPE) as protection agent on induced-glucose Mesangial cells (SV40 MES 13 cell line (Glomerular Mesangial Kidney, Mus Musculus)). Materials and Methods: MPE was performed based on maceration method. Cytotoxic assay was performed based on MTS (3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2Htetrazolium) method, while the level of TGF-β 1 (Transforming growth factor-β 1) and Fibronectin in glucoseinduced Mesangial cells were assayed and determined using ELISA KIT. Results: In viability assay, MPE 5 and 20 μ g/ml has the highest activity to increase cells proliferation in glucose-induced Mesangial cells at 5, 10, and 15 days of incubation in glucose concentration (5 and 25 mM) (P<0. 05). In inhibitory activity of TGF-β 1 and Fibronectin level, MPE 5 μ g/ml (glucose-induced 5 mM) show the lowest level compared to positive control and other treatments (P<0. 05). Conclusion: MPE can increase cell proliferation in glucose-induced Mesangial cells and significantly reduce the level of TGF-β 1 and Fibronectin. MPE activity has correlates to inhibit the diabetic Glomerulosclerosis condition and may increase Mesangial cell proliferation.

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    Cite

    APA: Copy

    WIDOWATI, WAHYU, Laksmitawati, Dian Ratih, WARGASETIA, TERESA LILIANA, Afifah, Ervi, Amalia, Annisa, Arinta, Yukko, Rizal, Rizal, & Suciati, Tri. (2018). Mangosteen peel extract (Garcinia mangostana L. ) as protective agent in glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(9), 972-977. SID. https://sid.ir/paper/725801/en

    Vancouver: Copy

    WIDOWATI WAHYU, Laksmitawati Dian Ratih, WARGASETIA TERESA LILIANA, Afifah Ervi, Amalia Annisa, Arinta Yukko, Rizal Rizal, Suciati Tri. Mangosteen peel extract (Garcinia mangostana L. ) as protective agent in glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(9):972-977. Available from: https://sid.ir/paper/725801/en

    IEEE: Copy

    WAHYU WIDOWATI, Dian Ratih Laksmitawati, TERESA LILIANA WARGASETIA, Ervi Afifah, Annisa Amalia, Yukko Arinta, Rizal Rizal, and Tri Suciati, “Mangosteen peel extract (Garcinia mangostana L. ) as protective agent in glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 9, pp. 972–977, 2018, [Online]. Available: https://sid.ir/paper/725801/en

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