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Information Journal Paper

Title

Adiponectin alleviates blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats

Pages

  1013-1019

Abstract

 Objective(s): The purpose of this study was to detect the protective effects of Adiponectin on coagulation dysfunction and its mechanism in Sepsis of Rats. Materials and Methods: The experimental samples were composed of sham group, model group that was underwent cecal ligation and puncture (CLP) and three Adiponectin treatment groups that treated by Adiponectin with different dose (72 μ g/kg, 96 μ g/kg and 120 μ g/kg) after CLP. The prothrombin time (PT), activated partial thromboplastin time (APTT) was measured, respectively, the level of malondialdehyde (MDA), tissue factor (TF), activated coagulation factor VIIa and Xa, p-selectin were detected, the histology structure of vascular was observed, the expressions of Caspase 9, Caspase 3, Bax, Bcl-2 and vWF in vascular were measured. Results: The results demonstrated that Adiponectin treatment lengthened PT and APTT, reduced the expression of MDA, TF, activated coagulation factor VIIa, Xa and p-selectin in plasma of septic Rats. Additionally, Adiponectin treatment alleviated endothelial cell Apoptosis and Oxidative stress, downregulated the levels of Caspase 3, Caspase 9, Bax, Bcl-2 and vWF in vascular. Conclusion: These findings suggest that Adiponectin treatment might be a promising therapeutic strategy for relieving septic endothelial cell injury and coagulation dysfunction via inhibiting endothelial cell Apoptosis in septic Rats.

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    Cite

    APA: Copy

    Hou, Yun, Wang, Xi Feng, Lang, Zhi Qiang, Zhao, Wei, Jin, Yinchuan, Zhang, Hong Qin, & Zhang, Lian Shuang. (2018). Adiponectin alleviates blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(10), 1013-1019. SID. https://sid.ir/paper/725829/en

    Vancouver: Copy

    Hou Yun, Wang Xi Feng, Lang Zhi Qiang, Zhao Wei, Jin Yinchuan, Zhang Hong Qin, Zhang Lian Shuang. Adiponectin alleviates blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(10):1013-1019. Available from: https://sid.ir/paper/725829/en

    IEEE: Copy

    Yun Hou, Xi Feng Wang, Zhi Qiang Lang, Wei Zhao, Yinchuan Jin, Hong Qin Zhang, and Lian Shuang Zhang, “Adiponectin alleviates blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 10, pp. 1013–1019, 2018, [Online]. Available: https://sid.ir/paper/725829/en

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