مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

230
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

83
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Effect of dehydroepiandrosterone on meiotic spindle structure and oocyte quality in mice

Pages

  1020-1025

Abstract

 Objective(s): Dehydroepiandrosterone (DHEA) has been reported to improve Pregnancy chances in women with diminished ovarian reserve (DOR) and to reduce miscarriage rates by 50– 80%. This study, therefore, assesses effects of DHEA on number of retrieved oocytes and Meiotic spindles. Materials and Methods: A randomized, prospective, controlled study was conducted on eight groups, four groups of young Mice and four elderly. All young and old groups received different oral doses (35, 50, 75 mg/kg) of DHEA for 3 months. Meiotic spindle assessment was done by immunocytochemical techniques using a confocal laser microscope (Leica TCS-4D). Results: Statistical surveys showed that in control young groups 80% (P=0. 0845) and in the old control group 73. 3% (P=0. 000) of the Meiotic spindles have a normal shape and structure; the difference was meaningful. The young with 50 mg/kg of DHEA in 85. 4% and the young with 75 mg/kg of DHEA in 84. 2% were normal in shape and structure. Statistical analysis showed that the difference was meaningless (P=0. 845). The old group with 30 mg/kg of DHEA in 81. 1%, the old with 50 mg/kg of DHEA in 83. 9%, and the old with 75 mg/kg of DHEA in 79. 0% showed normal shape and structure. The Meiotic spindle disruption ratio in old Mice showed a significant difference (P=0. 000) in comparison with others in young groups. Statistical analysis showed that difference between DHEA and control groups is meaningful. But this difference was meaningless between DHEA groups. Conclusion: Results showed that DHEA has a positive and improvement effect on the Meiotic spindle in old Mice.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    EFTEKHARI MOGHADAM, ALI REZA, SAKI, GHASEM, HEMADI, MASOUD, MAZAHERI, ZOHREH, & KHODADADI, ALI. (2018). Effect of dehydroepiandrosterone on meiotic spindle structure and oocyte quality in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(10), 1020-1025. SID. https://sid.ir/paper/725830/en

    Vancouver: Copy

    EFTEKHARI MOGHADAM ALI REZA, SAKI GHASEM, HEMADI MASOUD, MAZAHERI ZOHREH, KHODADADI ALI. Effect of dehydroepiandrosterone on meiotic spindle structure and oocyte quality in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(10):1020-1025. Available from: https://sid.ir/paper/725830/en

    IEEE: Copy

    ALI REZA EFTEKHARI MOGHADAM, GHASEM SAKI, MASOUD HEMADI, ZOHREH MAZAHERI, and ALI KHODADADI, “Effect of dehydroepiandrosterone on meiotic spindle structure and oocyte quality in mice,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 10, pp. 1020–1025, 2018, [Online]. Available: https://sid.ir/paper/725830/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button