مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Serum interleukin-18 and extent of coronary artery disease in unstable angina

Pages

  122-127

Abstract

 BACKGROUND: Interleukin-18 (IL-18) is an inflammatory marker with challenging role in Atherosclerosis. The present study was carried out aiming to evaluate the association between IL-18 serum level and extent and severity of Atherosclerosis among young patients with Unstable Angina (UA) who underwent coronary Angiography. METHODS: This cross sectional study was performed from July to October 2015 in Chamran heart center, Isfahan, Iran. 180 patients with UA in the age range of below 50 years entered the study. All demographic, past history, physical examination, electrocardiogram (EKG or ECG), and transthoracic echocardiogram (TTE) data were collected. Serum level of IL-18 was measured using enzyme-linked immunosorbent assay (ELISA) method. A coronary Angiography was performed on all patients to evaluate the presence and the incidence rate of coronary artery disease (CAD). RESULTS: Mean age of the patients was 46. 0 ± 4. 6 years [47. 4 ± 4. 3 and 45. 9 ± 4. 9 among patients with CAD and normal coronary, respectively (P = 0. 040)]. Rate of severe CAD was greater among men compared to women with values 67. 8% and 51. 8%, respectively (P = 0. 032). The median [interquartile range (IQR)] value of serum IL-18 among patients with CAD [192. 86 (128. 03, 325. 75)] was higher than normal coronary subjects [172. 81 (139. 77, 243. 21)], however it was not significant (198. 4 ± 93. 5, P = 0. 287). A significant difference between serum IL-18 level and number of stenosis vessels was detected only among women (P = 0. 032). CONCLUSION: Serum IL-18 level can predict the number of coronary arteries with significant stenosis among women with Unstable Angina.

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    APA: Copy

    SADEGHI, MASOUMEH, Gheraati, Maryam, SOLEIMANI, AZAM, Amirpour, Afshin, TAHERI, MARZIEH, YAZDEKHASTI, SAFOURA, & Valikhani, Elham. (2018). Serum interleukin-18 and extent of coronary artery disease in unstable angina. ARYA ATHEROSCLEROSIS, 14(3 (54)), 122-127. SID. https://sid.ir/paper/726200/en

    Vancouver: Copy

    SADEGHI MASOUMEH, Gheraati Maryam, SOLEIMANI AZAM, Amirpour Afshin, TAHERI MARZIEH, YAZDEKHASTI SAFOURA, Valikhani Elham. Serum interleukin-18 and extent of coronary artery disease in unstable angina. ARYA ATHEROSCLEROSIS[Internet]. 2018;14(3 (54)):122-127. Available from: https://sid.ir/paper/726200/en

    IEEE: Copy

    MASOUMEH SADEGHI, Maryam Gheraati, AZAM SOLEIMANI, Afshin Amirpour, MARZIEH TAHERI, SAFOURA YAZDEKHASTI, and Elham Valikhani, “Serum interleukin-18 and extent of coronary artery disease in unstable angina,” ARYA ATHEROSCLEROSIS, vol. 14, no. 3 (54), pp. 122–127, 2018, [Online]. Available: https://sid.ir/paper/726200/en

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