The Effect of Radiation Emitted by Cell Phone on The Gelatinolytic Activity of Matrix Metalloproteinase-2 and-9 of Mouse Pre-Antral Follicles during In Vitro Culture

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Azimipour Fariba; ZAVAREH SAEED; LASHKARBOLOUKI TAGHI

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Journal: Cell Journal (Yakhteh) Year:2020 | Volume:22 | Issue:1 Page(s): 1-8

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Title

The Effect of Radiation Emitted by Cell Phone on The Gelatinolytic Activity of Matrix Metalloproteinase-2 and-9 of Mouse Pre-Antral Follicles during In Vitro Culture

Author(s)

Azimipour Fariba | ZAVAREH SAEED | LASHKARBOLOUKI TAGHI | Issue Writer Certificate

Keywords

Cell Phone

Gelatinase

Ovarian Follicles

Radiation

Abstract

Objective: The unfavorable effects of electromagnetic Radiation (EMR) emitted by the Cell Phone on reproduction health are controversial. Metalloproteinases play a vital role in ovarian follicle development. This study was designed to investigate the effects of exposure to the Cell Phone on the gelatinolytic activity of in vitro cultured mouse pre-antral follicle. Materials and Methods: In this experimental study, pre-antral follicles were isolated from ovaries of immature mice (n=16) and cultured with or without exposure to the Cell Phone in talking mode for 60 minutes. The gelatinolytic activity was evaluated through the zymography method, as well as the gene expression of matrix metalloproteinases (MMPs) namely MMP-2 and-9 and tissue inhibitors of metalloproteinases (TIMPs) namely, TIMP-1 and-2 by the real-time polymerase chain reaction (PCR) method. Also, in parallel, the development of pre-antral follicles was assessed. Results: The maturation parameters of the Cell Phone-exposed pre-antral follicles were significantly lower compared with the control group (P<0. 05). The gelatinolytic activity was significantly decreased in the Cell Phone-exposed preantral follicles compared with the control group (P<0. 05). The relative mRNA expression of the MMP-2 gene was significantly (P<0. 05) increased in the Cell Phone-exposed pre-antral follicles whereas the expression rate of the MMP-9 gene was considerably (P<0. 05) reduced when compared with the control group. Conversely, the relative expression of the TIMP-1 was markedly (P<0. 05) increased in the Cell Phone-exposed pre-antral follicles while the expression of the TIMP-2 was (P<0. 05) significantly diminished in comparison with the control group. Conclusion: Exposure to the Cell Phone alters the growth and maturation rate of murine ovarian follicle through the changing in the expression of the MMP-2 and-9 genes, as well as the gelatinolytic activity.

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APA: Copy

Azimipour, Fariba, ZAVAREH, SAEED, & LASHKARBOLOUKI, TAGHI. (2020). The Effect of Radiation Emitted by Cell Phone on The Gelatinolytic Activity of Matrix Metalloproteinase-2 and-9 of Mouse Pre-Antral Follicles during In Vitro Culture. CELL JOURNAL (YAKHTEH), 22(1), 1-8. SID. https://sid.ir/paper/726356/en

Vancouver: Copy

Azimipour Fariba, ZAVAREH SAEED, LASHKARBOLOUKI TAGHI. The Effect of Radiation Emitted by Cell Phone on The Gelatinolytic Activity of Matrix Metalloproteinase-2 and-9 of Mouse Pre-Antral Follicles during In Vitro Culture. CELL JOURNAL (YAKHTEH)[Internet]. 2020;22(1):1-8. Available from: https://sid.ir/paper/726356/en

IEEE: Copy

Fariba Azimipour, SAEED ZAVAREH, and TAGHI LASHKARBOLOUKI, “The Effect of Radiation Emitted by Cell Phone on The Gelatinolytic Activity of Matrix Metalloproteinase-2 and-9 of Mouse Pre-Antral Follicles during In Vitro Culture,” CELL JOURNAL (YAKHTEH), vol. 22, no. 1, pp. 1–8, 2020, [Online]. Available: https://sid.ir/paper/726356/en

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