Significant roles played by interleukin-10 in outcome of pregnancy

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MOBINI MASOUD; MORTAZAVI MARYAM; Nadi Somayeh; ZARE BIDAKI MOHAMMAD; POURTALEBI SOMAYEH; KAZEMI ARABABADI MOHAMMAD

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:2 Page(s): 119-124

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Title

Significant roles played by interleukin-10 in outcome of pregnancy

Author(s)

Keywords

IL-10

Preterm delivery

Term delivery

Abstract

Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-10 (IL-10) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-10 during pregnancy may result in several pathologic conditions such as preterm labor. IL-10 leads to a normal pregnancy via several molecular mechanisms including development of tolerogenic dendritic cells, T regulatory lymphocytes and activation of the JAK1/STAT3 pathway in the target cells. This review has collected recent data regarding the status of IL-10 expression during term and preterm deliveries and also its molecular mechanisms that lead to a normal pregnancy.

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APA: Copy

MOBINI, MASOUD, MORTAZAVI, MARYAM, Nadi, Somayeh, ZARE BIDAKI, MOHAMMAD, POURTALEBI, SOMAYEH, & KAZEMI ARABABADI, MOHAMMAD. (2016). Significant roles played by interleukin-10 in outcome of pregnancy. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(2), 119-124. SID. https://sid.ir/paper/726438/en

Vancouver: Copy

MOBINI MASOUD, MORTAZAVI MARYAM, Nadi Somayeh, ZARE BIDAKI MOHAMMAD, POURTALEBI SOMAYEH, KAZEMI ARABABADI MOHAMMAD. Significant roles played by interleukin-10 in outcome of pregnancy. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(2):119-124. Available from: https://sid.ir/paper/726438/en

IEEE: Copy

MASOUD MOBINI, MARYAM MORTAZAVI, Somayeh Nadi, MOHAMMAD ZARE BIDAKI, SOMAYEH POURTALEBI, and MOHAMMAD KAZEMI ARABABADI, “Significant roles played by interleukin-10 in outcome of pregnancy,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 2, pp. 119–124, 2016, [Online]. Available: https://sid.ir/paper/726438/en

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