The protective effect of infliximab against carbon tetrachloride-induced acute lung injury

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Kurt Aysel; TUMKAYA LEVENT; YUCE SULEYMAN; Turut Hasan; Cure Medine Cumhur; SEHITOGLU IBRAHIM; KALKAN YILDIRAY; Pusuroglu Gokhan; CURE ERKAN

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Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:6 Page(s): 685-691

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Title

The protective effect of infliximab against carbon tetrachloride-induced acute lung injury

Author(s)

Keywords

Carbon tetrachloride

Infliximab

Nitric oxide

Pulmonary toxicity

Oxidative stress

Abstract

Objective(s): Carbon tetrachloride (CCl4) causes Pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α ). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. Materials and Methods: Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4. Results: TNF-α , malondialdehyde (MDA), Nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. The CCI4+Ib group had lower histopathological injury than the CCl4 group. Conclusion: Ib as a strong TNF-α blocker decreases the production of proinflammatory cytokines, MDA, and Oxidative stress leading to a protective effect against CCl4 induced lung tissue injury.

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APA: Copy

Kurt, Aysel, TUMKAYA, LEVENT, YUCE, SULEYMAN, Turut, Hasan, Cure, Medine Cumhur, SEHITOGLU, IBRAHIM, KALKAN, YILDIRAY, Pusuroglu, Gokhan, & CURE, ERKAN. (2016). The protective effect of infliximab against carbon tetrachloride-induced acute lung injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(6), 685-691. SID. https://sid.ir/paper/726487/en

Vancouver: Copy

Kurt Aysel, TUMKAYA LEVENT, YUCE SULEYMAN, Turut Hasan, Cure Medine Cumhur, SEHITOGLU IBRAHIM, KALKAN YILDIRAY, Pusuroglu Gokhan, CURE ERKAN. The protective effect of infliximab against carbon tetrachloride-induced acute lung injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(6):685-691. Available from: https://sid.ir/paper/726487/en

IEEE: Copy

Aysel Kurt, LEVENT TUMKAYA, SULEYMAN YUCE, Hasan Turut, Medine Cumhur Cure, IBRAHIM SEHITOGLU, YILDIRAY KALKAN, Gokhan Pusuroglu, and ERKAN CURE, “The protective effect of infliximab against carbon tetrachloride-induced acute lung injury,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 6, pp. 685–691, 2016, [Online]. Available: https://sid.ir/paper/726487/en

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