مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

211
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

133
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Abnormal hippocampal miR-1b expression is ameliorated by regular treadmill exercise in the sleep-deprived female rats

Pages

  485-490

Abstract

 Objective(s): The protective effect of regular running on Sleep deprivation (SD)-induced cognitive impairment has been revealed. In this study, we focused on the effects of regular exercise, Sleep deprivation and both of them together on the microRNA-1b (Mir-1b) expression and their relation to the behavioral parameters and brain-derived neurotrophic factor (BDNF) expression. Materials and Methods: We used ovariectomized (OVX) Female rats. The exercise program was mildmoderate Treadmill training for 4 weeks. 72 hr SD was achieved using the multiple platform method and the spatial learning and memory parameters have been evaluated by the Morris water maze (MWM) test. The levels of studied genes were quantified by real-time PCR. Results: SD down-regulated pri-Mir-1b, Mir-1b (P˂ 0. 05), and BDNF mRNA (P˂ 0. 01) in the Hippocampus. Furthermore, Female rats under exercise conditions showed significant up-regulation of the Mir-1b and BDNF mRNA (P˂ 0. 001). In addition, Mir-1b positively correlated with cognitive function (P˂ 0. 05) and BDNF mRNA (P˂ 0. 01). Conclusion: Our data demonstrated that regular treadmill exercise could reverse the down-regulation of hippocampal Mir-1b, which has a probable role in the SD-induced cognitive impairment.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Mohammadipoor ghasemabad, Lily, SANGTARASH, MOHAMMAD HOSSEIN, ESMAEILI MAHANI, SAEED, SHEIBANI, VAHID, & Sasan, Hosein Ali. (2019). Abnormal hippocampal miR-1b expression is ameliorated by regular treadmill exercise in the sleep-deprived female rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(5), 485-490. SID. https://sid.ir/paper/726581/en

    Vancouver: Copy

    Mohammadipoor ghasemabad Lily, SANGTARASH MOHAMMAD HOSSEIN, ESMAEILI MAHANI SAEED, SHEIBANI VAHID, Sasan Hosein Ali. Abnormal hippocampal miR-1b expression is ameliorated by regular treadmill exercise in the sleep-deprived female rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(5):485-490. Available from: https://sid.ir/paper/726581/en

    IEEE: Copy

    Lily Mohammadipoor ghasemabad, MOHAMMAD HOSSEIN SANGTARASH, SAEED ESMAEILI MAHANI, VAHID SHEIBANI, and Hosein Ali Sasan, “Abnormal hippocampal miR-1b expression is ameliorated by regular treadmill exercise in the sleep-deprived female rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 5, pp. 485–490, 2019, [Online]. Available: https://sid.ir/paper/726581/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button