The role of microRNA-30a and downstream snail1 on the growth and metastasis of melanoma tumor

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Noori Jahangir; HAGHJOOY JAVANMARD SHAGHAYEGH; Sharifi Mohamadreza

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:5 Page(s): 534-540

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Information Journal Paper

Title

The role of microRNA-30a and downstream snail1 on the growth and metastasis of melanoma tumor

Author(s)

Noori Jahangir | HAGHJOOY JAVANMARD SHAGHAYEGH | Sharifi Mohamadreza | Issue Writer Certificate

Keywords

Epithelial-mesenchymal-transition

Melanoma

Metastasis

miR-30a

Neoplasm

Snail1

Abstract

aggression. On the other hand, a phenomenon known as epithelial-mesenchymal transition (EMT) that indicates a transient phase from epithelial-like features to mesenchymal phenotype is a key player in tumor progression. In this study, we aimed to assess the potential impacts of miR-30a-5p as an inhibitor of Melanoma progression and Metastasis. Materials and Methods: miR-30a-5p was transfected into B16-F10 Melanoma cells. Then, the B16-F10 cells were injected subcutaneously or intravenously (IV) in to C57BL/6 mice. Then, the mice were euthanized and tumor size, tumor weight, Snail1 protein expression and nodules in the lungs were evaluated. Results: The migration of cancerous cells was significantly suppressed in vitro following the ectopic presentation of miR-30a-5p into B16-F10 Melanoma cells. Furthermore, the metastatic behavior of the neoplastic cells was further suppressed in a xenograft mouse model of Melanoma as observed with limited lung infiltration. We also found that transfected miR-30a-5p into Melanoma cells could decrease Snail1 and N-cadherin expression. Conclusion: miR-30a-5p may represent an effective therapeutic target for the management of Melanoma and other snail-overexpressing Neoplasms.

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APA: Copy

Noori, Jahangir, HAGHJOOY JAVANMARD, SHAGHAYEGH, & Sharifi, Mohamadreza. (2019). The role of microRNA-30a and downstream snail1 on the growth and metastasis of melanoma tumor. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(5), 534-540. SID. https://sid.ir/paper/726585/en

Vancouver: Copy

Noori Jahangir, HAGHJOOY JAVANMARD SHAGHAYEGH, Sharifi Mohamadreza. The role of microRNA-30a and downstream snail1 on the growth and metastasis of melanoma tumor. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(5):534-540. Available from: https://sid.ir/paper/726585/en

IEEE: Copy

Jahangir Noori, SHAGHAYEGH HAGHJOOY JAVANMARD, and Mohamadreza Sharifi, “The role of microRNA-30a and downstream snail1 on the growth and metastasis of melanoma tumor,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 5, pp. 534–540, 2019, [Online]. Available: https://sid.ir/paper/726585/en

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