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Information Journal Paper

Title

Signaling pathways involved in chronic myeloid leukemia pathogenesis: The importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells

Pages

  581-589

Abstract

 Objective(s): Chronic myeloid leukemia (CML) is a myeloid clonal proliferation disease defining by the presence of the Philadelphia chromosome that shows the movement of BCR-ABL1. In this study, the critical role of the Musashi2-Numb axis in determining cell fate and relationship of the axis to important Signaling pathways such as Hedgehog and Notch that are essential for Self-renewal pathways in CML stem cells will be reviewed meticulously. Materials and Methods: In this review, a PubMed search using the keywords of Leukemia, Signaling pathways, Musashi2-Numb was performed, and then we summarized different research works. Results: Although tyrosine kinase inhibitors such as Imatinib significantly kill and remove the cell with BCR-ABL1 translocation, they are unable to target BCR-ABL1 leukemia stem cells. The main problem is stem cells resistance to Imatinib therapy. Therefore, the identification and control of downstream molecules/ signaling route of the BCR-ABL1 that are involved in the survival and Self-renewal of leukemia stem cells can be an effective treatment strategy to eliminate leukemia stem cells, which supposed to be cured by Musashi2-Numb signaling pathway. Conclusion: The control of molecules /pathways downstream of the BCR-ABL1 and targeting Musashi2-Numb can be an effective therapeutic strategy for treatment of chronic leukemia stem cells. While Musashi2 is a poor prognostic marker in leukemia, in treatment and strategy, it has significant diagnostic value.

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    Cite

    APA: Copy

    Moradi, Foruzan, BABASHAH, SADEGH, SADEGHIZADEH, MAJID, HAJIFATHALI, ABBAS, & ROSHANDEL, ELHAM. (2019). Signaling pathways involved in chronic myeloid leukemia pathogenesis: The importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(6), 581-589. SID. https://sid.ir/paper/726587/en

    Vancouver: Copy

    Moradi Foruzan, BABASHAH SADEGH, SADEGHIZADEH MAJID, HAJIFATHALI ABBAS, ROSHANDEL ELHAM. Signaling pathways involved in chronic myeloid leukemia pathogenesis: The importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(6):581-589. Available from: https://sid.ir/paper/726587/en

    IEEE: Copy

    Foruzan Moradi, SADEGH BABASHAH, MAJID SADEGHIZADEH, ABBAS HAJIFATHALI, and ELHAM ROSHANDEL, “Signaling pathways involved in chronic myeloid leukemia pathogenesis: The importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 6, pp. 581–589, 2019, [Online]. Available: https://sid.ir/paper/726587/en

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