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Information Journal Paper

Title

Allicin attenuates tunicamycin-induced cognitive deficits in rats via its synaptic plasticity regulatory activity

Pages

  676-682

Abstract

 Objective(s): To illuminate the functional effects of Allicin on rats with cognitive deficits induced by tunicamycin (TM) and the molecular mechanism of this process. Materials and Methods: 200– 250 g male SD rats were divided into three groups at random: control group (n=12), TM group (5 μ l, 50 μ M, i. c. v, n=12), and Allicin treatment group (180 mg/kg/d with chow diet, n=12). After 16 weeks of Allicin treatment, the learning ability and memory were tested using novel object recognition (NOR) testing on rats with 72 hr TM treatment (5 μ l, 50 μ M, i. c. v); meanwhile, the variation of field excitatory postsynaptic potential (fEPSP) in the Schaffer Collateral (SC)-CA1 synapse was detected by extracellular electrophysiological recordings and the morphology of dendritic spine was observed by Golgi staining as well as detecting several Synaptic plasticity-related proteins by Western blot. Results: The density of dendritic spine was increased significantly in Allicin-treated groups and the correspondence slope of fEPSP in TM-induced cognitive deficits group was enhanced and expression of synaptophysin and glutamate receptor-1(GluR1) in hippocampal neurons was up-regulated. Conclusion: The results indicate that Allicin plays an important role in Synaptic plasticity regulation. These finding showed that Allicin could be used as a pharmacologic treatment in TM-induced cognitive deficits.

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    APA: Copy

    Xiang, Qiong, Li, Xian hui, YANG, BO, Fang, Xin xing, JIA, JING, Ren, Jie, Dong, Yu chun, Ou Yang, Cheng, & Wang, Guang cheng. (2017). Allicin attenuates tunicamycin-induced cognitive deficits in rats via its synaptic plasticity regulatory activity. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(6), 676-682. SID. https://sid.ir/paper/726650/en

    Vancouver: Copy

    Xiang Qiong, Li Xian hui, YANG BO, Fang Xin xing, JIA JING, Ren Jie, Dong Yu chun, Ou Yang Cheng, Wang Guang cheng. Allicin attenuates tunicamycin-induced cognitive deficits in rats via its synaptic plasticity regulatory activity. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(6):676-682. Available from: https://sid.ir/paper/726650/en

    IEEE: Copy

    Qiong Xiang, Xian hui Li, BO YANG, Xin xing Fang, JING JIA, Jie Ren, Yu chun Dong, Cheng Ou Yang, and Guang cheng Wang, “Allicin attenuates tunicamycin-induced cognitive deficits in rats via its synaptic plasticity regulatory activity,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 6, pp. 676–682, 2017, [Online]. Available: https://sid.ir/paper/726650/en

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