Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

LEE HUI YOUNG; TAE HYUN JIN; Cho Geum Sil; KIM IN HYE; CHO JEONG HWI; PARK JOON HA; AHN JI HYEON; CHEN BAI HUI; SHIN BICH NA; WON MOO HO; PARK CHAN WOO; CHO JUN HWI; Seo Jeong Yeol; LEE JAE CHUL

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:6 Page(s): 624-631

Download Full-Text

View:

204

Download:

316

Cites:

Information Journal Paper

Title

Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury

Author(s)

Keywords

myb Cells in stratum pyramidale Delayed neuronal death Ischemic preconditioning Ischemia

reperfusion Protection

Abstract

Objective(s): In the present study, we investigated the effect of ischemic preconditioning (IPC) on c-myb immunoreactivity as well as neuronal damage/death after a subsequent lethal transient ischemia in gerbils. Materials and Methods: IPC was subjected to a 2 min sublethal ischemia and a lethal transient ischemia was given 5 min transient ischemia. The animals in all of the groups were given recovery times of 1 day, 2 days and 5 days and we examined change in c-myb immunoreactivity as well as neuronal damage/death in the hippocampus induced by a lethal transient ischemia. Results: A lethal transient ischemia induced a significant loss of cells in the stratum pyramidale (SP) of the hippocampal CA1 region at 5 days post-ischemia, and this insult showed that c-myb immunoreactivity in cells of the SP of the CA1 region was significantly decreased at 2 days post-ischemia and disappeared at 5 days post-ischemia. However, IPC effectively prevented the neuronal loss in the SP and showed that c-myb immunoreactivity was constitutively maintained in the SP after a lethal transient ischemia. Conclusion: Our results show that a lethal transient ischemia significantly decreased c-myb immunoreactivity in the SP of the CA1 region and that IPC well preserved c-myb immunoreactivity in the SP of the CA1 region. We suggest that the maintenance of c-myb might be related with IPC-mediated neuroprotection after a lethal ischemic insult.

Cites

No record.

References

No record.

Cite

APA: Copy

LEE, HUI YOUNG, TAE, HYUN JIN, Cho, Geum Sil, KIM, IN HYE, CHO, JEONG HWI, PARK, JOON HA, AHN, JI HYEON, CHEN, BAI HUI, SHIN, BICH NA, WON, MOO HO, PARK, CHAN WOO, CHO, JUN HWI, Seo, Jeong Yeol, & LEE, JAE CHUL. (2016). Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(6), 624-631. SID. https://sid.ir/paper/726675/en

Vancouver: Copy

LEE HUI YOUNG, TAE HYUN JIN, Cho Geum Sil, KIM IN HYE, CHO JEONG HWI, PARK JOON HA, AHN JI HYEON, CHEN BAI HUI, SHIN BICH NA, WON MOO HO, PARK CHAN WOO, CHO JUN HWI, Seo Jeong Yeol, LEE JAE CHUL. Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(6):624-631. Available from: https://sid.ir/paper/726675/en

IEEE: Copy

HUI YOUNG LEE, HYUN JIN TAE, Geum Sil Cho, IN HYE KIM, JEONG HWI CHO, JOON HA PARK, JI HYEON AHN, BAI HUI CHEN, BICH NA SHIN, MOO HO WON, CHAN WOO PARK, JUN HWI CHO, Jeong Yeol Seo, and JAE CHUL LEE, “Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 6, pp. 624–631, 2016, [Online]. Available: https://sid.ir/paper/726675/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops