Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

198
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

132
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Y CHROMOSOME MICRODELETIONS IN INFERTILE MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA AND SEVERE OLIGOZOOSPERMIA

Pages

  307-315

Abstract

 Background: The purpose of the study was to investigate the frequencies and types of Y CHROMOSOME MICRODELETIONs in infertile men and to analyze the relationship between the levels of REPRODUCTIVE HORMONEs and Y microdeletions.Methods: A total of 1, 226 infertile men were screened for Y CHROMOSOME MICRODELETIONs using multiplex PCR assay. Karyotype analysis was performed on peripheral blood lymphocytes with standard G-banding. Serum REPRODUCTIVE HORMONE levels were measured.Results: Out of 1, 226 infertile patients, 134 (10.93%) had Y microdeletions. One hundred seven of 765 (13.99%) non-obstructive azoospermic patients and 27 of 133 (20.30%) severe oligozoospermic patients had Y microdeletions. Among the 134 infertile men with Y microdeletions, the most frequent microdeletions were detected in the AZFc region, followed by AZFbc, AZFb, AZFa, AZFabc (Yq), Yp (SRY)+Yq, and partial AZFc regions. Karyotype analysis was available for 130 of the 134 patients with Y microdeletions. Of them, 36 (27.69%) patients had sex chromosomal abnormalities. Levels of FSH and LH in patients with AZFc microdeletion were significantly lower, while those in patients with Yp (SRY)+Yq were significantly higher than in patients without Y microdeletions. Level of testosterone in patients with AZFabc (Yq) or Yp (SRY)+Yq was significantly lower than that in patients without Y microdeletions. However, there was no significant difference in the levels of REPRODUCTIVE HORMONEs between all patients with and without Y microdeletions.Conclusion: These results highlight the need for Y CHROMOSOME MICRODELETION screening for correct diagnosis of MALE INFERTILITY. Obtaining reliable genetic information for assisted reproductive techniques can prevent unnecessary treatment and vertical transmission of genetic defects to offspring.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    KIM, SHIN YOUNG, KIM, HYUN JIN, LEE, BOM YI, PARK, SO YEON, LEE, HYO SERK, & SEO, JU TAE. (2017). Y CHROMOSOME MICRODELETIONS IN INFERTILE MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA AND SEVERE OLIGOZOOSPERMIA. JOURNAL OF REPRODUCTION AND INFERTILITY, 18(3), 307-315. SID. https://sid.ir/paper/727603/en

    Vancouver: Copy

    KIM SHIN YOUNG, KIM HYUN JIN, LEE BOM YI, PARK SO YEON, LEE HYO SERK, SEO JU TAE. Y CHROMOSOME MICRODELETIONS IN INFERTILE MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA AND SEVERE OLIGOZOOSPERMIA. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2017;18(3):307-315. Available from: https://sid.ir/paper/727603/en

    IEEE: Copy

    SHIN YOUNG KIM, HYUN JIN KIM, BOM YI LEE, SO YEON PARK, HYO SERK LEE, and JU TAE SEO, “Y CHROMOSOME MICRODELETIONS IN INFERTILE MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA AND SEVERE OLIGOZOOSPERMIA,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 18, no. 3, pp. 307–315, 2017, [Online]. Available: https://sid.ir/paper/727603/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top