Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial

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Modanloo Hamed; EFTEKHARIAN HAMIDREZA; Arabiun Hamidreza

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Journal Paper

Paper Information

Journal: JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES) Year:2018 | Volume:19 | Issue:3 Page(s): 189-196

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Information Journal Paper

Title

Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial

Author(s)

Modanloo Hamed | EFTEKHARIAN HAMIDREZA | Arabiun Hamidreza | Issue Writer Certificate

Keywords

Lamotrigine

Third Molar

Pain Management

Abstract

Statement of the Problem: Extraction of the impacted Third Molar is often associat-ed with severe postoperative pains, management of which are a big challenge. Lamotrigine is a new antiepileptic drug with pre-emptive analgesic properties, which is hypothesized to alleviate postoperative pain. Purpose: This study aimed to evaluate the efficacy of pre-operative administration of single oral 200 mg Lamotrigine in reducing the postoperative pain of impacted Third Molar surgery. Materials and Method: In this randomized controlled trial, 100 adult patients were divided into two groups (n= 50) to receive either 200 mg oral Lamotrigine or placebo 1 hour before the removal of impacted Third Molar. The patients were monitored for 4 hours in the recovery room and pain intensity was measured through visual analogue scale (VAS) for the next 12 hours at 30-minute intervals. The time and number of rescue analgesics used in 12 hours was also recorded. Results: Two groups were not statistically significantly different regarding the sever-ity of postoperative pain. (p= 0. 512) Conclusion: Accordingly, pre-emptive administration of Lamotrigine was not effec-tive in diminishing the postoperative acute pain of impacted Third Molar extraction.

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APA: Copy

Modanloo, Hamed, EFTEKHARIAN, HAMIDREZA, & Arabiun, Hamidreza. (2018). Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 19(3), 189-196. SID. https://sid.ir/paper/727805/en

Vancouver: Copy

Modanloo Hamed, EFTEKHARIAN HAMIDREZA, Arabiun Hamidreza. Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;19(3):189-196. Available from: https://sid.ir/paper/727805/en

IEEE: Copy

Hamed Modanloo, HAMIDREZA EFTEKHARIAN, and Hamidreza Arabiun, “Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 19, no. 3, pp. 189–196, 2018, [Online]. Available: https://sid.ir/paper/727805/en

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