Quercetin Decreases Th17 Production by Down-Regulation of MAPK-TLR4 Signaling Pathway on T Cells in Dental Pulpitis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Hashemi Ali Mahmoud; SOLAHAYE KAHNAMOUII SHIVA; AGHAJANI HASSAN; Frozannia Khalil; Pournasrollah Alireza; Sadegh Rasoul; Esmaeeli Heidarali; Ghadimi Yosef; RAZMPA EBRAHIM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES) Year:2018 | Volume:19 | Issue:4 Page(s): 259-264

Download Full-Text

View:

230

Download:

100

Cites:

Information Journal Paper

Title

Quercetin Decreases Th17 Production by Down-Regulation of MAPK-TLR4 Signaling Pathway on T Cells in Dental Pulpitis

Author(s)

Keywords

Quercetin

T-Lymphocytes

Protein kinase

Toll-Like Receptor 4

Pulpitis

Abstract

Statement of the Problem: Quercetin is a pharmacological flavonoid that can inhibit high mobility group box1 (HMGB1) protein, a non-histone nuclear protein that is implicated in inflammation. Th17 cells are important cells in the pathogene-sis of inflammation. Pulpitis is the inflammation of dental pulp, which usually is accompanied by pain. Quercetin may alleviate this inflammation. Purpose: The current study aimed to compare blocking of HMGB1 function and stimulation of HMGB1 function with Quercetin and investigate the effects of the blockage on T helper 17 (Th17) cells and mitogen-activated Protein kinase Toll-Like Receptor 4 (MAPK-TLR4) signaling pathway. Materials and Method: T cells isolated from the pulp involved with Pulpitis and the normal pulp were cultured. The cells suspensions were plated in 6-wells culture plates and stimulated with 0. 5 μ g/ml of HMGB1 for 2, 4, 8, and 12 hours. For blocking TLR4, 10 μ g/ml rabbit anti-human TLR4 antibody was added 1 hour before treatment with HMGB1. Results: The level of these cytokines decreased; moreover, western blot data showed that Quercetin could decrease MAPK signaling pathway by means of inhi-bition of HMGB1 on T cells. The results showed the reduction of TLR4 pathway and Th17 cell polarization. Conclusion: Our results indicated that the levels of IL-17, IL-33, and IL-6 in su-pernatants from patients’ cultured T cells were increased after stimulation with HMGB-1 following employing Quercetin. It also could inhibit MAPK signaling pathway, which subsequently could decrease Th17 production and IL-17. Quercetin could decrease pro-inflammatory cytokines and IL-17 production.

Cites

No record.

References

No record.

Cite

APA: Copy

Hashemi, Ali Mahmoud, SOLAHAYE KAHNAMOUII, SHIVA, AGHAJANI, HASSAN, Frozannia, Khalil, Pournasrollah, Alireza, Sadegh, Rasoul, Esmaeeli, Heidarali, Ghadimi, Yosef, & RAZMPA, EBRAHIM. (2018). Quercetin Decreases Th17 Production by Down-Regulation of MAPK-TLR4 Signaling Pathway on T Cells in Dental Pulpitis. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 19(4), 259-264. SID. https://sid.ir/paper/727809/en

Vancouver: Copy

Hashemi Ali Mahmoud, SOLAHAYE KAHNAMOUII SHIVA, AGHAJANI HASSAN, Frozannia Khalil, Pournasrollah Alireza, Sadegh Rasoul, Esmaeeli Heidarali, Ghadimi Yosef, RAZMPA EBRAHIM. Quercetin Decreases Th17 Production by Down-Regulation of MAPK-TLR4 Signaling Pathway on T Cells in Dental Pulpitis. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;19(4):259-264. Available from: https://sid.ir/paper/727809/en

IEEE: Copy

Ali Mahmoud Hashemi, SHIVA SOLAHAYE KAHNAMOUII, HASSAN AGHAJANI, Khalil Frozannia, Alireza Pournasrollah, Rasoul Sadegh, Heidarali Esmaeeli, Yosef Ghadimi, and EBRAHIM RAZMPA, “Quercetin Decreases Th17 Production by Down-Regulation of MAPK-TLR4 Signaling Pathway on T Cells in Dental Pulpitis,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 19, no. 4, pp. 259–264, 2018, [Online]. Available: https://sid.ir/paper/727809/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops