TOLL-LIKE RECEPTOR 2 (TLR-2) GENE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS

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ERMIS KARAALI ZEYNEP; CANDAN GONCA; BURAK AKTUGLU MEHMET; VELET MUSTAFA; ERGEN ARZU

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Journal Paper

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Journal: Cell Journal (Yakhteh) Year:2019 | Volume:20 | Issue:4 Page(s): 559-563

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Title

TOLL-LIKE RECEPTOR 2 (TLR-2) GENE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS

Author(s)

Keywords

DIABETES

INFLAMMATION

POLYMORPHISM

TLRS

Abstract

Objective: Innate immunity factors are associated with type 2 DIABETES (T2DM) and its complications. Therefore, T2DM has been suggested to be an immune-dependent disease. Elevated fasting glucose level and higher concentrations of innate immunity soluble molecules are not only related with insulin resistance, but INFLAMMATION is also an important factor in beta cell dysfunction in T2DM. Toll-like receptor 2(TLR-2), which has an important role in inducing innate immune cells, is thought to have suppressive roles on immune responses in T2DM. We therefore aimed to investigate the possible role ofTLR-2 del -196-174 and Arg753Gln variants in T2DM pathogenesis.Materials and Methods: This study was designed as a case-control study. Polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) technique was used to genotype the two variants in 100 T2DM patients and 98 agematched controls.Results: We found significantly higher frequencies of TLR-2 del -196-174 DD genotype (P=0.003), ID genotype (P=0.009) and D allele (P=0.001) in patients compared with controls. In addition, the II genotype (P=0.001) and the I allele (P=0.003) frequencies were elevated in healthy controls. We did not find any significant differences in frequency distribution for the Arg753Gln variant in study groups.Conclusion: We suggest that carrying the D allele of the TLR-2 del -196-174 variant may be related as a risk factor for T2DM.

Cites

Hardy Weinberg Equilibrium Disturbances in Case-Control Studies Lead to Non-Conclusive Results, Letter to The Editor

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APA: Copy

ERMIS KARAALI, ZEYNEP, CANDAN, GONCA, BURAK AKTUGLU, MEHMET, VELET, MUSTAFA, & ERGEN, ARZU. (2019). TOLL-LIKE RECEPTOR 2 (TLR-2) GENE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS. CELL JOURNAL (YAKHTEH), 20(4), 559-563. SID. https://sid.ir/paper/727937/en

Vancouver: Copy

ERMIS KARAALI ZEYNEP, CANDAN GONCA, BURAK AKTUGLU MEHMET, VELET MUSTAFA, ERGEN ARZU. TOLL-LIKE RECEPTOR 2 (TLR-2) GENE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS. CELL JOURNAL (YAKHTEH)[Internet]. 2019;20(4):559-563. Available from: https://sid.ir/paper/727937/en

IEEE: Copy

ZEYNEP ERMIS KARAALI, GONCA CANDAN, MEHMET BURAK AKTUGLU, MUSTAFA VELET, and ARZU ERGEN, “TOLL-LIKE RECEPTOR 2 (TLR-2) GENE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS,” CELL JOURNAL (YAKHTEH), vol. 20, no. 4, pp. 559–563, 2019, [Online]. Available: https://sid.ir/paper/727937/en

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