APLASTIC ANEMIA EVOLVING TO MYELODYSPLASTIC SYNDROME AND LATER TO A LYMPHOPROLIFERATIVE MALIGNANCY IN A TREATED CASE OF CARCINOMA BREAST: A CASE REPORT EMPHASIZING THE IMPORTANCE OF PET-CT IN CUTANEOUS T CELL LYMPHOMA

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PADMA SUBRAMANYAM; SUNDARAM PALANISWAMY SHANMUGA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Nuclear Medicine Year:2017 | Volume:25 | Issue:1 (SERIAL NUMBER 47) Page(s): 66-69

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Title

APLASTIC ANEMIA EVOLVING TO MYELODYSPLASTIC SYNDROME AND LATER TO A LYMPHOPROLIFERATIVE MALIGNANCY IN A TREATED CASE OF CARCINOMA BREAST: A CASE REPORT EMPHASIZING THE IMPORTANCE OF PET-CT IN CUTANEOUS T CELL LYMPHOMA

Author(s)

PADMA SUBRAMANYAM | SUNDARAM PALANISWAMY SHANMUGA | Issue Writer Certificate

Keywords

APLASTIC ANEMIA

MYELODYSPLASTIC SYNDROME

CYCLOSPORINE

CARCINOMA BREAST

METHOTREXATE

CUTANEOUS T CELL LYMPHOMA

Abstract

Although APLASTIC ANEMIA (AA) and MYELODYSPLASTIC SYNDROME (MDS) are separate entities with different management, distinction between the two can be difficult on morphological basis due to hypocellularity of bone marrow. MDS is one of the serious complications of AA. Karyotyping is definitive in the diagnosis of MDS. Better and robust investigations like18F-Fluoro-deoxy-Glucose Positron Emission Tomography/Computed Tomography (18F-FDG PET-CT) are essential in high risk patients with haematological malignancies and in those relapsing within a short period of time after initiation of therapy or having refractory disease. It might be helpful in the development of individual treatment algorithms for these high-risk patients. There may be unique problems in hematological malignancies where the transformation of one pathology into another may be silent with no biomarkers that can predict this transformation e.g. transformation of MDS from AA. Studies have shown that immune suppression can lead to a variety of haematological and lymphoproliferative disorders which may co-exist.18F-FDG PET-CT may be useful in identifying the primary or occult sites of malignancy and also can direct the site from which biopsy can be attempted. We present a patient with Carcinoma right breast who developed hematological and lymphoproliferative disorders during the course of her treatment. In this case, AA transformed to MDS with abnormal karyotype (chromosome 9 mutation) and then progressed further to manifest CUTANEOUS T CELL LYMPHOMA before patient succumbed to her illness. Immune mediated suppression of haemopoiesis has been considered the most important mechanism in this case.

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APA: Copy

PADMA, SUBRAMANYAM, & SUNDARAM, PALANISWAMY SHANMUGA. (2017). APLASTIC ANEMIA EVOLVING TO MYELODYSPLASTIC SYNDROME AND LATER TO A LYMPHOPROLIFERATIVE MALIGNANCY IN A TREATED CASE OF CARCINOMA BREAST: A CASE REPORT EMPHASIZING THE IMPORTANCE OF PET-CT IN CUTANEOUS T CELL LYMPHOMA. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 25(1 (SERIAL NUMBER 47)), 66-69. SID. https://sid.ir/paper/728302/en

Vancouver: Copy

PADMA SUBRAMANYAM, SUNDARAM PALANISWAMY SHANMUGA. APLASTIC ANEMIA EVOLVING TO MYELODYSPLASTIC SYNDROME AND LATER TO A LYMPHOPROLIFERATIVE MALIGNANCY IN A TREATED CASE OF CARCINOMA BREAST: A CASE REPORT EMPHASIZING THE IMPORTANCE OF PET-CT IN CUTANEOUS T CELL LYMPHOMA. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2017;25(1 (SERIAL NUMBER 47)):66-69. Available from: https://sid.ir/paper/728302/en

IEEE: Copy

SUBRAMANYAM PADMA, and PALANISWAMY SHANMUGA SUNDARAM, “APLASTIC ANEMIA EVOLVING TO MYELODYSPLASTIC SYNDROME AND LATER TO A LYMPHOPROLIFERATIVE MALIGNANCY IN A TREATED CASE OF CARCINOMA BREAST: A CASE REPORT EMPHASIZING THE IMPORTANCE OF PET-CT IN CUTANEOUS T CELL LYMPHOMA,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 1 (SERIAL NUMBER 47), pp. 66–69, 2017, [Online]. Available: https://sid.ir/paper/728302/en

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