MITOCHONDRIA AS A TARGET FOR DRUG THERAPY IN EPILEPSY (POSTER PRESENTATION)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHIRI ELHAM; SHIRI AKRAM; BORHANI HAGHIGHI MARYAM; ALIPOUR FATEMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Neuroscience Journal of Shefaye Khatam Year:2018 | Volume:6 | Issue:3 (SUPPLEMENT 2) Page(s): 0-0

Download Full-Text

View:

239

Download:

Cites:

Information Journal Paper

Title

MITOCHONDRIA AS A TARGET FOR DRUG THERAPY IN EPILEPSY (POSTER PRESENTATION)

Author(s)

SHIRI ELHAM | SHIRI AKRAM | BORHANI HAGHIGHI MARYAM | ALIPOUR FATEMEH | Issue Writer Certificate

Keywords

EPILEPSY

DRUG

THERAPY

MITOCHONDRIA

Abstract

Introduction: EPILEPSY is one of the most common neurologic disorders, characterized by unprovoked, recurring seizures that interrupt the nervous system and can induce mental and physical dysfunction. MITOCHONDRIAl dysfunction and oxidative stress play a central role in several neurological disorders, and recently MITOCHONDRIAl dysfunction has been shown in acquired epilepsies. MITOCHONDRIAl dysfunction in repeated seizures can cause neuronal cell death which is an important characteristic of the DRUG-resistant type of EPILEPSY. MITOCHONDRIA are considered as targeted neuroprotective plans for a limited number of neurodegenerative disorders with MITOCHONDRIAl pathologies such as amyotrophic lateral sclerosis and Chorea Huntington. The creatine/phosphocreatine system, adjusted by MITOCHONDRIAl creatine kinase, plays an essential role in conserving energy balance in the brain. The buffering of neuronal energy levels by systemic creatine administration has been proposed for treatment. The supplemented creatine has been shown protective effect not only on neurodegenerative disorders but also on hypoxia-induced or traumatic brain injury. It was observed that creatin can reduce hypoxia-induced seizures but had the negative effect on temporal lobe EPILEPSY. Recent researches suggest that protection of MITOCHONDRIA and decrease of oxidative stress-related events represent hopeful therapeutic methods for the treatment of various disorders. Metabolic antioxidants such as lipoic acid, N-acetyl cysteine, CoQ10 were tested for a potential neuroprotective effect in EPILEPSY. ketogenic diets particularly showed an increase in MITOCHONDRIAl glutathione levels. Thus, current progress in developing MITOCHONDRIA-targeted antioxidants is a promising approach for new therapeutic methods not only in ischemia/reperfusion but also in human EPILEPSY.Conclusion: Treatment with compounds possessing antioxidant properties and targeting MITOCHONDRIAl dysfunction may in the future provide therapeutic strategies for the successful treatment of epilepsies.

Cites

No record.

References

No record.

Cite

APA: Copy

SHIRI, ELHAM, SHIRI, AKRAM, BORHANI HAGHIGHI, MARYAM, & ALIPOUR, FATEMEH. (2018). MITOCHONDRIA AS A TARGET FOR DRUG THERAPY IN EPILEPSY (POSTER PRESENTATION). NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 6(3 (SUPPLEMENT 2)), 0-0. SID. https://sid.ir/paper/728332/en

Vancouver: Copy

SHIRI ELHAM, SHIRI AKRAM, BORHANI HAGHIGHI MARYAM, ALIPOUR FATEMEH. MITOCHONDRIA AS A TARGET FOR DRUG THERAPY IN EPILEPSY (POSTER PRESENTATION). NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2018;6(3 (SUPPLEMENT 2)):0-0. Available from: https://sid.ir/paper/728332/en

IEEE: Copy

ELHAM SHIRI, AKRAM SHIRI, MARYAM BORHANI HAGHIGHI, and FATEMEH ALIPOUR, “MITOCHONDRIA AS A TARGET FOR DRUG THERAPY IN EPILEPSY (POSTER PRESENTATION),” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 6, no. 3 (SUPPLEMENT 2), pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/728332/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops