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Information Journal Paper

Title

Research Paper: Investigating Morphologic Changes andViability of Rats’ Bone Marrow Mesenchymal Stem Cellsin Microgravity

Pages

  99-105

Abstract

 Introduction: Mesenchymal Stem Cells (MSCs) are multipotent cells capable of duplicationand auto-recovery and distinction from various cells including chondrocytes, adipocytes, chondroblasts, fibroblasts, and osteoblasts. Human stem cells are always subject to localand external mechanical loads. External loads are caused by physical activity in externalenvironment loading to infliction of static and dynamic loads on the body and internal loadsare typically caused due to body physiological function. Mechanical factors can affect differentparameters such as morphology, proliferation, migration, metabolism and death as well aschemical changes in cells and lead to chemical changes in extracellular matrix and intracellularenvironment, besides distinction of cells. Methods: MSCs were isolated from Rat’ s bone marrow, then cultured in Microgravityconditions. Morphologic changes of cells were analyzed by taking pictures at different times. Results: Results indicated a reduction in cell area and an increase in cell aspect Ratio, inmicrogravity conditions. No significant difference was observed in cell angle of rotation atdifferent time measurements. Also, in measuring viability of these cells using MTT test it wasfound that Microgravity reduces viability of stem cells, considerably. Conclusion: Microgravity conditions have a considerable impact on morphology of MSCs. Furthermore, viability of MSCs decreased signi ficantly after 48 h, under Microgravity conditions.

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    Cite

    APA: Copy

    Monfaredi, Samira, DARABI, SHAHRAM, AHADI, REZA, & RAJAEI, FARZAD. (2017). Research Paper: Investigating Morphologic Changes andViability of Rats’ Bone Marrow Mesenchymal Stem Cellsin Microgravity. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 14(3), 99-105. SID. https://sid.ir/paper/728414/en

    Vancouver: Copy

    Monfaredi Samira, DARABI SHAHRAM, AHADI REZA, RAJAEI FARZAD. Research Paper: Investigating Morphologic Changes andViability of Rats’ Bone Marrow Mesenchymal Stem Cellsin Microgravity. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2017;14(3):99-105. Available from: https://sid.ir/paper/728414/en

    IEEE: Copy

    Samira Monfaredi, SHAHRAM DARABI, REZA AHADI, and FARZAD RAJAEI, “Research Paper: Investigating Morphologic Changes andViability of Rats’ Bone Marrow Mesenchymal Stem Cellsin Microgravity,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 14, no. 3, pp. 99–105, 2017, [Online]. Available: https://sid.ir/paper/728414/en

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