Circulating concentrations of interleukin (IL)-17 in patients with multiple sclerosis: Evaluation of the effects of gender, treatment, disease patterns and IL-23 receptor gene polymorphisms

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Ghaffari Seyed Ali; NEMATI MARYAM; Hajghani Hossain; EBRAHIMI HOSSEIN ALI; SHEIKHI ABDOLKARIM; JAFARZADEH ABDOLLAH

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Journal Paper

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Journal: Current Journal of Neurology Year:2017 | Volume:16 | Issue:1 Page(s): 15-25

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Title

Circulating concentrations of interleukin (IL)-17 in patients with multiple sclerosis: Evaluation of the effects of gender, treatment, disease patterns and IL-23 receptor gene polymorphisms

Author(s)

Keywords

Multiple Sclerosis

Interleukin-17

Gender

Treatment

Interleukin-23 Receptor

Gene Polymorphisms

Abstract

Background: Interleukin (IL)-17/IL-23 axis performs a prominent role in the pathogenesis of several autoimmune disorders. This study aimed to investigate the concentrations of IL-17 in patients with Multiple Sclerosis (MS) and its relationship with Gender, medication, disease forms and single nucleotide polymorphisms (SNP) in IL-23R gene, including rs11209026 and rs1004819. Methods: The blood specimens were obtained from 135 healthy individuals and 135 MS patients. The patients exhibited relapsing-remitting (RRMS; n = 65), primary progressive (PPMS; n = 19), secondary progressive (SPMS; n = 35) or progressive relapsing (PRMS; n = 14) MS. The DNA was analyzed for SNPs using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and IL-17 concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Results: We have observed elevated serum IL-17 concentrations in MS patients compared with healthy individuals (P < 0. 001). The men with MS had higher IL-17 concentrations than women patients (P < 0. 050). Untreated patients had significantly higher IL-17 concentrations than healthy individuals and treated patients (P < 0. 001 and P < 0. 010, respectively). The IL-17 concentrations were significantly decreased in patients treated with interferon-β (IFN-β ), methylprednisolone or both drugs as compared with untreated MS patients (P < 0. 050, P < 0. 020 and P < 0. 050, respectively). The IL-17 concentrations were also significantly higher in patients with RRMS and PRMS compared with healthy individuals (P < 0. 005 and P < 0. 010, respectively). The genetic variations at SNPs rs11209026 and rs1004819 were not significantly different between healthy individuals and patients. The IL-17 concentrations were not influenced by genetic variations at investigated SNPs. Conclusion: These results indicated higher levels of IL-17 in MS patients that may be influenced by disease patterns, medication and Gender. No association was observed between investigated SNPs and MS.

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APA: Copy

Ghaffari, Seyed Ali, NEMATI, MARYAM, Hajghani, Hossain, EBRAHIMI, HOSSEIN ALI, SHEIKHI, ABDOLKARIM, & JAFARZADEH, ABDOLLAH. (2017). Circulating concentrations of interleukin (IL)-17 in patients with multiple sclerosis: Evaluation of the effects of gender, treatment, disease patterns and IL-23 receptor gene polymorphisms. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 16(1), 15-25. SID. https://sid.ir/paper/729039/en

Vancouver: Copy

Ghaffari Seyed Ali, NEMATI MARYAM, Hajghani Hossain, EBRAHIMI HOSSEIN ALI, SHEIKHI ABDOLKARIM, JAFARZADEH ABDOLLAH. Circulating concentrations of interleukin (IL)-17 in patients with multiple sclerosis: Evaluation of the effects of gender, treatment, disease patterns and IL-23 receptor gene polymorphisms. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2017;16(1):15-25. Available from: https://sid.ir/paper/729039/en

IEEE: Copy

Seyed Ali Ghaffari, MARYAM NEMATI, Hossain Hajghani, HOSSEIN ALI EBRAHIMI, ABDOLKARIM SHEIKHI, and ABDOLLAH JAFARZADEH, “Circulating concentrations of interleukin (IL)-17 in patients with multiple sclerosis: Evaluation of the effects of gender, treatment, disease patterns and IL-23 receptor gene polymorphisms,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 16, no. 1, pp. 15–25, 2017, [Online]. Available: https://sid.ir/paper/729039/en

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