EFFECT OF MEDIUM-TERM INJECTION OF MDMA ON THE ANXIETY OF MALE RAT WITH PLUS MAZE TEST

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JAHANSHAHI M.; NIKMAHZAR E.G.; KHOSRAVI M.; SEID HOSSEINI F.

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Journal: Journal of Babol University of Medical Sciences Year:2012 | Volume:14 | Issue:6 (69) Page(s): 84-90

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Title

EFFECT OF MEDIUM-TERM INJECTION OF MDMA ON THE ANXIETY OF MALE RAT WITH PLUS MAZE TEST

Author(s)

JAHANSHAHI M. | NIKMAHZAR E.G. | KHOSRAVI M. | SEID HOSSEINI F. | Issue Writer Certificate

Keywords

METHYLENEDIOXYMETHAMPHETAMINEQ3

ANXIETYQ2

ELEVATED PLUS MAZEQ2

RATQ2

Abstract

BACKGROUND AND OBJECTIVE: Acute administration of METHYLENEDIOXYMETHAMPHETAMINE (MDMA) is produced dose-dependent effects on ANXIETY-related behaviors. High doses of MDMA have anxiolytic effects and low doses of MDMA increases ANXIETY-like behavior in the ELEVATED PLUS MAZE test. The aim of this study was to evaluate the sub-chronic (7 days) effects of low doses of MDMA on ANXIETY in the male RAT.METHODS: In the present experimental study, 28 male Wistar RATs were used with approximate weight 20±200 g. Animals were randomly divided into 4 groups, 7 RATs were used in each group and experimental groups for a week received different doses of MDMA (1.25, 2.5, 5 mg/kg) and sham group (1 ml/kg), received saline peritoneally. ANXIETY one day before injection and 30 minutes after the last injection was performed by the ELEVATED PLUS MAZE.FINDINGS: Injection of MDMA significantly increased open arm time percentage that the highest observed in the experimental group received a dose of 5 mg/kg with mean 29.77±33.337. With increasing dose of MDMA increased open arm entry percentage that the difference between experimental group received a dose of 2.5 mg/kg and saline group was statistically significant (p<0.05). MDMA decreased pure index of locomotor activity. MDMA decreased open arm latency that the experimental group received a dose of 2.5 mg/kg less delay in entering the open arm compared to the other experimental groups, averaging 70.83±114.188 showed.CONCLUSION: Low doses of MDMA in sub-chronic (7 day) period can reduce some indices of ANXIETY in the RATs.

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APA: Copy

JAHANSHAHI, M., NIKMAHZAR, E.G., KHOSRAVI, M., & SEID HOSSEINI, F.. (2012). EFFECT OF MEDIUM-TERM INJECTION OF MDMA ON THE ANXIETY OF MALE RAT WITH PLUS MAZE TEST. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 14(6 (69)), 84-90. SID. https://sid.ir/paper/72942/en

Vancouver: Copy

JAHANSHAHI M., NIKMAHZAR E.G., KHOSRAVI M., SEID HOSSEINI F.. EFFECT OF MEDIUM-TERM INJECTION OF MDMA ON THE ANXIETY OF MALE RAT WITH PLUS MAZE TEST. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2012;14(6 (69)):84-90. Available from: https://sid.ir/paper/72942/en

IEEE: Copy

M. JAHANSHAHI, E.G. NIKMAHZAR, M. KHOSRAVI, and F. SEID HOSSEINI, “EFFECT OF MEDIUM-TERM INJECTION OF MDMA ON THE ANXIETY OF MALE RAT WITH PLUS MAZE TEST,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 14, no. 6 (69), pp. 84–90, 2012, [Online]. Available: https://sid.ir/paper/72942/en

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