Vitamin D suppresses cellular pathways of diabetes complication in liver

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DERAKHSHANIAN HODA; DJALALI MAHMOUD; JAVANBAKHT MOHAMMAD HASSAN; ALVANDI EHSAN; ESHRAGHIAN MOHAMMAD REZA; MIRSHAFIEY ABBAS; Nadimi Hoda; Jahanabadi Samane; ZAREI MAHNAZ; DJAZAYERY ABOLGHASSEM

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:6 Page(s): 690-694

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Title

Vitamin D suppresses cellular pathways of diabetes complication in liver

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Keywords

Advanced glycation end-products

Cholecalciferol

Diabetes complications

Hexosamine pathway

Vitamin D

Abstract

Objective(s): The aim of this study was to investigate the effect of Vitamin D on glucose metabolism, as well as the expression of five key genes involved in the development of Diabetes complications in liver tissue of diabetic rats. Materials and Methods: Twenty-four male Sprague– Dawley rats were randomly divided into three groups (8 rats in each group). The first group served as control and the other two groups received an intraperitoneal injection of 45 mg/kg streptozotocin to develop diabetes. Groups were treated for four weeks either with placebo or Vitamin D (two injections of 20000 IU/kg). Thereafter, serum levels of glucose, insulin and HbA1c were assessed. Liver tissue was examined for the level of advanced glycation end products (AGEs) and the gene expression of AGE cellular receptor (AGER), glyoxalase-1 (GLO-1), aldose reductase (AR), O-linked N-acetylglucosamine transferase (OGT) and glutamine/ fructose-6-phosphate aminotransferase (GFAT). Results: Vitamin D injection resulted in a significant increase in plasma level of 25-hydroxyCholecalciferol, which could improve hyperglycemia about 11% compared to placebo-receiving diabetic rats (P=0. 005). Insulin level increased as a result of Vitamin D treatment compared to control (3. 31± 0. 65 vs. 2. 15± 0. 79; P= 0. 01). Serum HbA1c and liver AGE concentrations had a slight but insignificant reduction following Vitamin D intake. Moreover, a significant decline was observed in gene expression of AGER and OGT in liver tissue (P=0. 04 and P<0. 001 respectively). Conclusion: Vitamin D might contribute in ameliorating Diabetes complications not only by improving blood glucose and insulin levels, but also by suppressing AGER and OGT gene expression in the liver.

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APA: Copy

DERAKHSHANIAN, HODA, DJALALI, MAHMOUD, JAVANBAKHT, MOHAMMAD HASSAN, ALVANDI, EHSAN, ESHRAGHIAN, MOHAMMAD REZA, MIRSHAFIEY, ABBAS, Nadimi, Hoda, Jahanabadi, Samane, ZAREI, MAHNAZ, & DJAZAYERY, ABOLGHASSEM. (2019). Vitamin D suppresses cellular pathways of diabetes complication in liver. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(6), 690-694. SID. https://sid.ir/paper/730116/en

Vancouver: Copy

DERAKHSHANIAN HODA, DJALALI MAHMOUD, JAVANBAKHT MOHAMMAD HASSAN, ALVANDI EHSAN, ESHRAGHIAN MOHAMMAD REZA, MIRSHAFIEY ABBAS, Nadimi Hoda, Jahanabadi Samane, ZAREI MAHNAZ, DJAZAYERY ABOLGHASSEM. Vitamin D suppresses cellular pathways of diabetes complication in liver. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(6):690-694. Available from: https://sid.ir/paper/730116/en

IEEE: Copy

HODA DERAKHSHANIAN, MAHMOUD DJALALI, MOHAMMAD HASSAN JAVANBAKHT, EHSAN ALVANDI, MOHAMMAD REZA ESHRAGHIAN, ABBAS MIRSHAFIEY, Hoda Nadimi, Samane Jahanabadi, MAHNAZ ZAREI, and ABOLGHASSEM DJAZAYERY, “Vitamin D suppresses cellular pathways of diabetes complication in liver,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 6, pp. 690–694, 2019, [Online]. Available: https://sid.ir/paper/730116/en

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