The prevalence of exotoxins, adhesion, and biofilm-related genes in Staphylococcus aureus isolates from the main burn center of Tehran, Iran

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Mir Zahra; Nodeh Farahani Narges; Abbasian Sara; ALINEJAD FARANAK; SATTARZADEH TABRIZI MAHBOUBEH; Pouriran Ramin; DAHMARDEHEI MOSTAFA; MIRZAII MEHDI; Khoramrooz Seyed Sajjad; DARBAN SAROKHALIL DAVOOD

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:11 Page(s): 1267-1274

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Title

The prevalence of exotoxins, adhesion, and biofilm-related genes in Staphylococcus aureus isolates from the main burn center of Tehran, Iran

Author(s)

Keywords

MRSA

Virulence factors

Adhesin and biofilm genes

Burn

Iran

Abstract

Objective(s): The present study investigated the prevalence of genes encoding for exotoxins, adhesion and biofilm factors in Staphylococcus aureus isolates obtained from samples in a referral Burn hospital in Tehran, Iran. Materials and Methods: S. aureus isolates obtained from patients, personnel and surfaces in the wards of a Burn hospital were identified and confirmed by biochemical and molecular tests, respectively. The susceptibility of isolates was determined using the disk diffusion method. Virulence factors were detected by multiplex PCR. Results: The frequency of hla, hlb, hld, hlg, tst and pvl genes was 92. 8%, 34. 7%, 89. 8%, 11. 9%, 10. 7%, and 0. 5% respectively. The results revealed that the hla gene had the highest frequency among isolates (94. 4% for methicillin-resistant S. aureus (MRSA) and 89. 8% for methicillin-susceptible S. aureus (MSSA)). The most prevalent adhesion and biofilm-related gene was eno (85. 6%). The prevalence of the remaining genes was as follows: fib (71. 8%), clfB (70%), cna (59. 2 %), fnbB (17. 9%), icaA (72. 4%), and icaD (85. 6%). The incidence of fib, hlb, hlg, and tst genes was significantly higher in MRSA isolates compare to the MSSA isolates. Moreover, the resistance rates for all antibiotics were higher is MRSA isolates except for nitrofurantoin and chloramphenicol antibiotics. Conclusion: Data indicate the high prevalence rates of Virulence factors among S. aureus isolates, especially MRSA strains in the Burn hospital. This should to be taken into account in the development of an effective infection control policy and continuous monitoring of drug resistance in hospitals.

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APA: Copy

Mir, Zahra, Nodeh Farahani, Narges, Abbasian, Sara, ALINEJAD, FARANAK, SATTARZADEH TABRIZI, MAHBOUBEH, Pouriran, Ramin, DAHMARDEHEI, MOSTAFA, MIRZAII, MEHDI, Khoramrooz, Seyed Sajjad, & DARBAN SAROKHALIL, DAVOOD. (2019). The prevalence of exotoxins, adhesion, and biofilm-related genes in Staphylococcus aureus isolates from the main burn center of Tehran, Iran. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(11), 1267-1274. SID. https://sid.ir/paper/730128/en

Vancouver: Copy

Mir Zahra, Nodeh Farahani Narges, Abbasian Sara, ALINEJAD FARANAK, SATTARZADEH TABRIZI MAHBOUBEH, Pouriran Ramin, DAHMARDEHEI MOSTAFA, MIRZAII MEHDI, Khoramrooz Seyed Sajjad, DARBAN SAROKHALIL DAVOOD. The prevalence of exotoxins, adhesion, and biofilm-related genes in Staphylococcus aureus isolates from the main burn center of Tehran, Iran. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(11):1267-1274. Available from: https://sid.ir/paper/730128/en

IEEE: Copy

Zahra Mir, Narges Nodeh Farahani, Sara Abbasian, FARANAK ALINEJAD, MAHBOUBEH SATTARZADEH TABRIZI, Ramin Pouriran, MOSTAFA DAHMARDEHEI, MEHDI MIRZAII, Seyed Sajjad Khoramrooz, and DAVOOD DARBAN SAROKHALIL, “The prevalence of exotoxins, adhesion, and biofilm-related genes in Staphylococcus aureus isolates from the main burn center of Tehran, Iran,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 11, pp. 1267–1274, 2019, [Online]. Available: https://sid.ir/paper/730128/en

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