Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats

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Yayla Muhammed; Cetin Damla; Adali Yasemen; Kilicle Pinar Aksu; Toktay Erdem

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:12 Page(s): 1262-1268

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Title

Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats

Author(s)

Keywords

Ischemia/Reperfusion

Oxidative stress

Ovary

Pomegranate seed oil

Punicaceae

Rats

Abstract

Objective(s): The aim of this study is to determine the therapeutic effects of Pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in Rats. Materials and Methods: Fifty-six female albino Wistar Rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia, Group 3; Ischemia + Reperfusion, Group 4; Ischemia + Pomegranate 0, 32 ml / kg (IP), Group 5; Ischemia + Pomegranate 0. 64 ml / kg, Group 6; Ischemia + Pomegranate 0, 32 ml / kg + reperfusion, Group 7; Ischemia + Pomegranate 0, 64 ml / kg + reperfusion. Three hours after ischemia and 3 hours after reperfusion, the study was terminated. Results: While NADPH oxidase activity, MDA and TNF-α levels were significantly increased, SOD activity and GSH levels were reduced in ischemia and I/R groups. Low dose Pomegranate seed oil application reduced significantly Oxidative stress and NADPH oxidase activity in both ischemic and ischemic/reperfusion groups. At the same time, low-dose Pomegranate seed oil extract reduced TNF-α levels and significantly increased antioxidant activity. Conclusion: PSO demonstrated an important therapeutic effect in the treatment of ovarian ischemia and reperfusion injury.

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APA: Copy

Yayla, Muhammed, Cetin, Damla, Adali, Yasemen, Kilicle, Pinar Aksu, & Toktay, Erdem. (2018). Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(12), 1262-1268. SID. https://sid.ir/paper/730130/en

Vancouver: Copy

Yayla Muhammed, Cetin Damla, Adali Yasemen, Kilicle Pinar Aksu, Toktay Erdem. Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(12):1262-1268. Available from: https://sid.ir/paper/730130/en

IEEE: Copy

Muhammed Yayla, Damla Cetin, Yasemen Adali, Pinar Aksu Kilicle, and Erdem Toktay, “Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 12, pp. 1262–1268, 2018, [Online]. Available: https://sid.ir/paper/730130/en

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