Vitamin D, the gut microbiome and inflammatory bowel disease (Review Article)

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Tabatabaeizadeh Seyed Amir; Tafazoli Niayesh; FERNS GORDON A.; AVAN AMIR; GHAYOUR MOBARHAN MAJID

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Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2018 | Volume:23 | Issue:8 Page(s): 0-0

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Title

Vitamin D, the gut microbiome and inflammatory bowel disease (Review Article)

Author(s)

Keywords

Gut microbiome

inflammatory bowel diseases

Vitamin D

Abstract

Vitamin D has an important role in bone metabolism but recently has been recognized as an immunoregulator, and this has led to investigations on the effect of Vitamin D supplementation in various autoimmune diseases and its anti‑ inflammatory effects. There is some evidence that Vitamin D can regulate gastrointestinal inflammation. In addition, previous studies have shown that Vitamin D can affect the Gut microbiome. The aim of this review is to evaluate the effect of Vitamin D on inflammatory processes, especially its relation to the inflammatory bowel disease (IBD) and Gut microbiome. There is some evidence that Vitamin D can regulate gastrointestinal inflammation, with epidemiological studies showing that individuals with higher serum Vitamin D have a lower incidence of IBD, particularly Crohn’ s disease. Vitamin D changes transcription of cathelicidin and DEFB4 (defensin, beta 4) that can affect the Gut microbiome. Several cell types of the immune system express Vitamin D receptor, and hence the use of Vitamin D in immune regulation has some potential. Furthermore, Vitamin D deficiency leads to dysbiosis of Gut microbiome and reported to cause severe colitis. Vitamin D supplementation is low cost and available and can be a therapeutic option.

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Vitamin D and GUT Microbiota: A Review

References

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APA: Copy

Tabatabaeizadeh, Seyed Amir, Tafazoli, Niayesh, FERNS, GORDON A., AVAN, AMIR, & GHAYOUR MOBARHAN, MAJID. (2018). Vitamin D, the gut microbiome and inflammatory bowel disease (Review Article). JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 23(8), 0-0. SID. https://sid.ir/paper/730296/en

Vancouver: Copy

Tabatabaeizadeh Seyed Amir, Tafazoli Niayesh, FERNS GORDON A., AVAN AMIR, GHAYOUR MOBARHAN MAJID. Vitamin D, the gut microbiome and inflammatory bowel disease (Review Article). JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2018;23(8):0-0. Available from: https://sid.ir/paper/730296/en

IEEE: Copy

Seyed Amir Tabatabaeizadeh, Niayesh Tafazoli, GORDON A. FERNS, AMIR AVAN, and MAJID GHAYOUR MOBARHAN, “Vitamin D, the gut microbiome and inflammatory bowel disease (Review Article),” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 23, no. 8, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/730296/en

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