The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharidetreated rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BEHESHTI FARIMAH; HOSSEINI MAHMOUD; Hashemzehi Milad; SOUKHTANLOO MOHAMMAD; KHAZAEI MAJID; SHAFEI MOHAMMAD NASER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:8 Page(s): 940-948

Download Full-Text

View:

194

Download:

166

Cites:

Information Journal Paper

Title

The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharidetreated rats

Author(s)

Keywords

Brain-derived neurotrophic-factor

Cytokines learning

Lipopolysaccharide

Memory

Pioglitazone

Abstract

Objective(s): The aim of current study was to evaluate improving effects of Pioglitazone as an agonist of peroxisome proliferator-activated receptor gamma (PPARγ ), on brain-derived neurotrophic factor (BDNF) and cytokines as well as tissue oxidative damage criteria in the hippocampus in a rat model of Lipopolysaccharide (LPS) induced Memory impairment. Materials and Methods: The rats were classified and treated as follows (10 rats per group): (1) vehicle, (2) vehicle before LPS (1 mg/kg, 120 min before Memory tests), (3-5) Pioglitazone 10, 20 or 30 mg/kg 30 min before LPS. Finally, the hippocampal tissues were collected for biomedical analyses. Results: In the Morris water maze test, the LPS group, had a longer latency to find the platform while they spent a shorter time in the target quadrant in the probe trial. In the passive avoidance test, the animals of the LPS group had shorter delay times to enter the dark compartment than those of the control group. Treatment with 20 and 30 mg of Pioglitazone corrected these parameters. In the hippocampus of LPS group interleukin-6, tumor necrosis factor-α , nitric oxide metabolites, and malondialdehyde were higher while thiol, BDNF, and IL-10 concentrations and the activities of catalase (CAT) and superoxide dismutase (SOD) were lower than the control group. Treatment by both doses of 20 and 30 mg of Pioglitazone corrected the biochemical parameters in the hippocampus. Conclusion: The current findings revealed that Pioglitazone protected the rats from learning and Memory impairment induced by LPS. The effects were associated with improvement of cytokines, oxidative stress criteria, and BDNF.

Cites

The effects of pre-treatment with olibanum and its constituent, boswellic acid on synaptic plasticity impairments induced by lipopolysaccharide in rats

References

No record.

Cite

APA: Copy

HOSSEINI, MAHMOUD, Hashemzehi, Milad, SOUKHTANLOO, MOHAMMAD, KHAZAEI, MAJID, & SHAFEI, MOHAMMAD NASER. (2019). The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharidetreated rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(8), 940-948. SID. https://sid.ir/paper/730460/en

Vancouver: Copy

HOSSEINI MAHMOUD, Hashemzehi Milad, SOUKHTANLOO MOHAMMAD, KHAZAEI MAJID, SHAFEI MOHAMMAD NASER. The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharidetreated rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(8):940-948. Available from: https://sid.ir/paper/730460/en

IEEE: Copy

MAHMOUD HOSSEINI, Milad Hashemzehi, MOHAMMAD SOUKHTANLOO, MAJID KHAZAEI, and MOHAMMAD NASER SHAFEI, “The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharidetreated rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 8, pp. 940–948, 2019, [Online]. Available: https://sid.ir/paper/730460/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops