مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway

Pages

  1340-1346

Abstract

 Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces Autophagy in Cardiomyocytes injury. This study aims to evaluate the effects of Eupafolin on LPS-induced Cardiomyocyte Autophagy. Materials and Methods: The effect of LPS on cell viability was examined by CCK-8. Autophagic protein 2 light chain 3 (LC3II), which was regulated by LPS and Eupafolin, was examined using immunofluorescent staining. The expression levels of Beclin-1 and p62 were detected by western blotting. The effects of Eupafolin on phosphatidylinositol-3-kinase/ protein kinase B/ mammalian target of rapamycin (PI3K/ AKT/mTOR) signaling pathway were also evaluated by western blotting and immunofluorescent staining. Results: Eupafolin pretreatment reduced the expression of LC3II and Beclin-1, whereas p62 was significant increased. In addition, Eupafolin promoted expression of PI3K/AKT/mTOR signaling pathway and mTOR inhibitor rapamycin reversed the inhibitory effects on LPS-induced Cardiomyocyte Autophagy. Conclusion: Eupafolin exerts anti-Autophagy activity via activation of PI3K/AKT/mTOR signaling pathway.

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    Cite

    APA: Copy

    GAO, YAN, ZHANG, YI, & Fan, Yangyang. (2019). Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(11), 1340-1346. SID. https://sid.ir/paper/730845/en

    Vancouver: Copy

    GAO YAN, ZHANG YI, Fan Yangyang. Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(11):1340-1346. Available from: https://sid.ir/paper/730845/en

    IEEE: Copy

    YAN GAO, YI ZHANG, and Yangyang Fan, “Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 11, pp. 1340–1346, 2019, [Online]. Available: https://sid.ir/paper/730845/en

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