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Information Journal Paper

Title

Attenuation of lipid peroxidation and atherogenic factors in diabetic patients treated with gliclazide and metformin

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Abstract

 Background: Diabetes is associated with oxidative stress and considered as a major risk factor for cardiac disease. We attempted to investigate the role of oral antidiabetic (OAD) agents gliclazide and metformin in lowering the lipid peroxidation and managing the risk for cardiovascular (CV) complications in diabetic patients in comparison with nondiabetic healthy individuals. Materials and Methods: This cross‑ sectional study was comprised of 150 individuals grouped in three, namely, Group A (n = 60) healthy volunteers, Group B (n = 30) newly diagnosed diabetes, and Group C (n = 60) diabetes treated with OAD. Serum malondialdehyde (MDA), nitric oxide (NO), and Vitamin C were assessed for studying lipid peroxidation status, whereas serum triglyceride (TG) and total cholesterol were monitored as predictors for CV risk. Results: We found significantly higher concentrations of MDA and NO levels (P < 0. 001) in both groups of patients (Group B and C) in comparison to control group (Group A). Regarding Antioxidants, significantly lower concentrations of Vitamin C (P = 0. 046) were found in Group B and C compared to Group A. Moreover, there was significant difference exhibited in concentration level of MDA (P = 0. 001) and NO (P = 0. 015) between Group B and C, whereas difference of Vitamin C (P = 0. 147) was not statistically significant. Conclusion: Our data confirmed that treatment with gliclazide and metformin significantly reduced the lipid peroxidation accompanied with attenuated levels of serum TGs and cholesterol and suggested that oral hypoglycemic agents have great impact to reduce the oxidative stress and increase the Antioxidant status in diabetes.

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    APA: Copy

    Banik, Sujan, Hossain, Mohammad Salim, Bhatta, Rita, & Akter, Mariyam. (2018). Attenuation of lipid peroxidation and atherogenic factors in diabetic patients treated with gliclazide and metformin. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 23(8), 0-0. SID. https://sid.ir/paper/731015/en

    Vancouver: Copy

    Banik Sujan, Hossain Mohammad Salim, Bhatta Rita, Akter Mariyam. Attenuation of lipid peroxidation and atherogenic factors in diabetic patients treated with gliclazide and metformin. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2018;23(8):0-0. Available from: https://sid.ir/paper/731015/en

    IEEE: Copy

    Sujan Banik, Mohammad Salim Hossain, Rita Bhatta, and Mariyam Akter, “Attenuation of lipid peroxidation and atherogenic factors in diabetic patients treated with gliclazide and metformin,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 23, no. 8, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/731015/en

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