مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Rhopalurus junceus scorpion venom induces antitumor effect in vitro and in vivo against a murine mammary adenocarcinoma model

Pages

  759-765

Abstract

 Objective(s): In Cuba the endemic scorpion species Rhopalurus junceus has been used in traditional medicine for cancer treatment and related diseases. However there is no scientific evidence about its therapeutic potential for cancer treatment. The aim of the study was to determine the Antitumor effect of Scorpion venom against a murine mammary adenocarcinoma F3II. Materials and Methods: The cytotoxic activity was determined by MTT assay with venom concentrations ranging from 0. 1– 1 mg/ml. Apoptosis was determined by RT-PCR and flow cytometry. Toxic effect in healthy animals and tumor growth kinetics in F3II bearing-mice were evaluated by using Scorpion venom doses (0. 2; 0. 8; 3. 2 mg/kg) after one and ten injections respectively by the intraperitoneal route. Results: Scorpion venom induced a significant cytotoxic effect (P<0. 05) in F3II cells in a concentrationdependent manner. The cell death event involves the apoptotic pathway due to up-regulation of proapoptotic genes (p53, bax), down-regulation of antiapoptotic gene (bcl-2), and 33% of Annexin V+/ PI-cells at early Apoptosis and 10. 21% of Annexin V+/PI+ cells at late Apoptosis. Scorpion venom induced significant inhibition of tumor progression (P<0. 05) in F3II bearing-mice in a dose-dependent manner. The Antitumor effect was confirmed due to dose-dependent reduction of Ki-67 and CD31 proteins present in tumor tissue. Conclusion: Evidence indicates that Scorpion venom can be an attractive natural product for deep investigation and developing a novel therapeutic agent for breast cancer treatment.

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    Cite

    APA: Copy

    Diaz Garcia, Alexis, Ruiz Fuentes, Jenny Laura, Frion Herrera, Yahima, Yglesias Rivera, Arianna, Garlobo, Yanelis Riquenez, Rodriguez Sanchez, Hermis, Rodriguez Aurrecochea, Juan C, & Lopez Fuentes, Ledys X. (2019). Rhopalurus junceus scorpion venom induces antitumor effect in vitro and in vivo against a murine mammary adenocarcinoma model. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(7), 759-765. SID. https://sid.ir/paper/731141/en

    Vancouver: Copy

    Diaz Garcia Alexis, Ruiz Fuentes Jenny Laura, Frion Herrera Yahima, Yglesias Rivera Arianna, Garlobo Yanelis Riquenez, Rodriguez Sanchez Hermis, Rodriguez Aurrecochea Juan C, Lopez Fuentes Ledys X. Rhopalurus junceus scorpion venom induces antitumor effect in vitro and in vivo against a murine mammary adenocarcinoma model. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(7):759-765. Available from: https://sid.ir/paper/731141/en

    IEEE: Copy

    Alexis Diaz Garcia, Jenny Laura Ruiz Fuentes, Yahima Frion Herrera, Arianna Yglesias Rivera, Yanelis Riquenez Garlobo, Hermis Rodriguez Sanchez, Juan C Rodriguez Aurrecochea, and Ledys X Lopez Fuentes, “Rhopalurus junceus scorpion venom induces antitumor effect in vitro and in vivo against a murine mammary adenocarcinoma model,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 7, pp. 759–765, 2019, [Online]. Available: https://sid.ir/paper/731141/en

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