The efficacy and molecular mechanism of the effect of schisandrin b on the treatment of erectile dysfunction

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LIU WEI; Zhao Chen; HUANG YANPING; Liu Yidong; Lu Mujun

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:8 Page(s): 866-871

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Title

The efficacy and molecular mechanism of the effect of schisandrin b on the treatment of erectile dysfunction

Author(s)

Keywords

cAMP-PKA pathway

Cyclic nucleotides

Erectile dysfunction

Intracavernosum pressure

NO-cGMP pathway

Schisandrin b

Abstract

Objective(s): The purpose of this study is to determine the efficacy and molecular mechanism of the effect of Schisandrin b (SCHB) on treating Erectile dysfunction (ED) in a rat model with bilateral cavernous crushing nerve injury. Materials and Methods: The ED rat model was established with bilateral cavernous nerve crushing, and then confirmed by apomorphine. Fifty healthy eight-week-old ED rats were randomly assigned into five group, including control group (sham surgery), bilateral cavernous nerve crushing injury group (BCNC), BCNC with low SCHB (100 mg/d), BCNC with medium SCHB (200 mg/d) and BCNC with high SCHB (400 mg/d). For the last three groups, SCHB was given for 2 months. Then, we examined intracavernosal pressure (ICP), Cyclic nucleotides (cAMP, cGMP), endothelial nitric oxide synthase (eNOS) and neuronal NOS (nNOS) in all groups. Results: In the study of ICP, SCHB was able to improve ED in a dose-dependent manner. In addition, as compared to the BCNC group, the relative expression of eNOS and nNOS in medium and high concentration of SCHB-treated groups are higher than BCNC group. Moreover, all groups treated with SCHB showed a significant higher expression level of cAMP and cGMP. Conclusion: These results suggested that SCHB were able to significantly improve the ED on rat model through the NO-cGMP and cAMP-protein kinase A (PKA) pathway.

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APA: Copy

LIU, WEI, Zhao, Chen, HUANG, YANPING, Liu, Yidong, & Lu, Mujun. (2019). The efficacy and molecular mechanism of the effect of schisandrin b on the treatment of erectile dysfunction. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(8), 866-871. SID. https://sid.ir/paper/731146/en

Vancouver: Copy

LIU WEI, Zhao Chen, HUANG YANPING, Liu Yidong, Lu Mujun. The efficacy and molecular mechanism of the effect of schisandrin b on the treatment of erectile dysfunction. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(8):866-871. Available from: https://sid.ir/paper/731146/en

IEEE: Copy

WEI LIU, Chen Zhao, YANPING HUANG, Yidong Liu, and Mujun Lu, “The efficacy and molecular mechanism of the effect of schisandrin b on the treatment of erectile dysfunction,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 8, pp. 866–871, 2019, [Online]. Available: https://sid.ir/paper/731146/en

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