Crocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism

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Kamyar Marzyeh; RAZAVI BIBI MARJAN; VAHDATI HASANI FAEZEH; MEHRI SOGHRA; Foroutanfar Amir; HOSSEINZADEH HOSSEIN

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Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:10 Page(s): 1070-1079

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Title

Crocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism

Author(s)

Keywords

Crocin

Haloperidol

Lipid peroxidation

Orofacial dyskinesia

Oxidative stress

Abstract

Objective(s): Long-term treatment with antipsychotics causes serious side effects such as tardive dyskinesia that characterized by abnormal movements in the orofacial region. Oxidative stress in the brain specific area is implicated in the pathophysiology of tardive dyskinesia. In this study the protective effect of Crocin on Haloperidol-induced Orofacial dyskinesia was evaluated. Materials and Methods: Haloperidol (1 mg/kg, IP) and Crocin (10, 20 and 40 mg/kg, IP) were administrated to rats for 21 days. Behavioral assessments such as Orofacial dyskinesia movements, open field test and elevated plus maze (EPM) were evaluated every week. Malondealdehyde (MDA) and glutathione (GSH) levels in the hippocampus, cortex and striatum were also measured. Results: Haloperidol increased vacuous chewing movements (VCMs) and tongue protrusions (TPs) in rats and co-administration of Crocin (20 and 40 mg/kg) significantly reduced them. Furthermore, Haloperidol decreased the locomotor and exploratory activities (rearing) in the open field test and decreased the percentage of entries into open arms and the percentage of the time spent on open arms in the EPM. Pretreatment with Crocin (10 mg/kg) modified Haloperidol effects on these behavioral parameters. Haloperidol induced Lipid peroxidation in three brain regions, whereas Crocin co-administration reduced the MDA and restored the decreased GSH levels. Conclusion: Our finding suggests that Oxidative stress has an important role in the development of tardive dyskinesia. Crocin showed protective effect against Haloperidol induced tardive dyskinesia and as a potent naturally antioxidant could be a new and useful drug and a possible therapeutic option for the treatment of tardive dyskinesia.

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APA: Copy

Kamyar, Marzyeh, RAZAVI, BIBI MARJAN, VAHDATI HASANI, FAEZEH, MEHRI, SOGHRA, Foroutanfar, Amir, & HOSSEINZADEH, HOSSEIN. (2016). Crocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(10), 1070-1079. SID. https://sid.ir/paper/731160/en

Vancouver: Copy

Kamyar Marzyeh, RAZAVI BIBI MARJAN, VAHDATI HASANI FAEZEH, MEHRI SOGHRA, Foroutanfar Amir, HOSSEINZADEH HOSSEIN. Crocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(10):1070-1079. Available from: https://sid.ir/paper/731160/en

IEEE: Copy

Marzyeh Kamyar, BIBI MARJAN RAZAVI, FAEZEH VAHDATI HASANI, SOGHRA MEHRI, Amir Foroutanfar, and HOSSEIN HOSSEINZADEH, “Crocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 10, pp. 1070–1079, 2016, [Online]. Available: https://sid.ir/paper/731160/en

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