COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL, FAILURE AND HEMODIALYTIC PATIENTS

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RAFIEI ALI REZA; MAKHLOGH A.; HASHEMINASAB SADEGH; MAHDAVI MOHAMMAD REZA; MIRABI A.M.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2008 | Volume:10 | Issue:1 (42) Page(s): 20-27

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Title

COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL, FAILURE AND HEMODIALYTIC PATIENTS

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Keywords

CHRONIC RENALFAILWEQ3

HEAMODIALYSISQ3

CD26Q3

CD30Q3

Abstract

BACKGROUND AND OBJECTIVE: Various abnonnalities of the immune system have been demonstrated in patients on hemodialysis. Imbalances in Th1 and Th2 responses have an important role in these complications. These cells produce predominantly some cytokine profiles and also express preferentially co-stimulatory CD26 and CD30 molecules. The aim of the present study was to determine the levels of soluble CD26 and CD30 co-stimulatory molecules in sera of chronic renal failure (CRF) and hemodialytic patients (HD).METHODS: This case-control study was performed on 60 CRF patients (30 patients with CRF and 30 end-stage renal diseases under hemodialysis) and 60 healthy individuals. Renal function was evaluated by measuring serum levels of creatinine, albumin and urea. The serum levels of soluble CD26 and CD30 were determined by a sandwich enzyme-linked immunosorbent assay.FINDINGS: The serum levels of CD26 in the BD, CP.F patients, and healthy controls were 275.4±125.6, 402.9±103.1, and 389.2±117ng/ml, respectively. The level of CD26 was significantly decreased in the BD group compared to the CRF and control groups (p=0.002).On the other hand, the serum levels of CD30 in the BD, CRF patients, and healthy controls were 45.3±13.7, 38.9±14.5, 20.7±10.5 U/ml, respectively. The CD30 levels were significantly higher in BD and CRF patients than controls (p<0.0001).There was no significant difference between BD and CRF groups (p=0.05).CONCLUSION: High serum levels of CD30 in line with low expression ofCD26 indicate a th2 polarization in immune responses of BD patients. It is possible that this th2-dominated immune response may contribute to the abnormality of the immune system in BD patients.

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APA: Copy

RAFIEI, ALI REZA, MAKHLOGH, A., HASHEMINASAB, SADEGH, MAHDAVI, MOHAMMAD REZA, & MIRABI, A.M.. (2008). COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL, FAILURE AND HEMODIALYTIC PATIENTS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 10(1 (42)), 20-27. SID. https://sid.ir/paper/73123/en

Vancouver: Copy

RAFIEI ALI REZA, MAKHLOGH A., HASHEMINASAB SADEGH, MAHDAVI MOHAMMAD REZA, MIRABI A.M.. COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL, FAILURE AND HEMODIALYTIC PATIENTS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2008;10(1 (42)):20-27. Available from: https://sid.ir/paper/73123/en

IEEE: Copy

ALI REZA RAFIEI, A. MAKHLOGH, SADEGH HASHEMINASAB, MOHAMMAD REZA MAHDAVI, and A.M. MIRABI, “COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL, FAILURE AND HEMODIALYTIC PATIENTS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 10, no. 1 (42), pp. 20–27, 2008, [Online]. Available: https://sid.ir/paper/73123/en

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