DGC/Zeta as A New Strategy to Improve Clinical Outcome in Male Factor Infertility Patients following Intracytoplasmic Sperm Injection: A Randomized, Single-Blind, Clinical Trial

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KARIMI Nazanin; MOHSENI KOUCHESFAHANI HOMA; NASR ESFAHANI MOHAMMAD HOSSEIN; TAVALAEE MARZIYEH; SHAHVERDI ABDOLHOSSEIN; CHOOBINEH HAMID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2020 | Volume:22 | Issue:1 Page(s): 55-59

Download Full-Text

View:

320

Download:

210

Cites:

Information Journal Paper

Title

DGC/Zeta as A New Strategy to Improve Clinical Outcome in Male Factor Infertility Patients following Intracytoplasmic Sperm Injection: A Randomized, Single-Blind, Clinical Trial

Author(s)

Keywords

DGC/Zeta

Embryo Quality

Fertilization

Pregnancy

Abstract

Objective: The aim of this blind randomised clinical trial study was to assess the clinical efficiency of combined density gradient centrifugation/Zeta (DGC/Zeta) sperm selection procedure compared to conventional DGC in infertile men candidates for intracytoplasmic sperm injection (ICSI). The literature shows that DGC/Zeta is more effective compared to DGC alone in selection of sperms with normal chromatin and improves the clinical outcome of the ICSI procedure. Therefore, this study re-evaluates the efficiency of DGC/Zeta in improving the clinical outcomes of ICSI in an independent clinical setting. Materials and Methods: In this randomized, single-blind, clinical trial, a total of 240 couples with male factor infertility and at least one abnormal sperm parameter were informed regarding the study and 220 participated. Based on inclusion and exclusion criteria, 103 and 102 couples were randomly allocated into the DGC/Zeta and DGC groups, respectively. ICSI outcomes were followed and compared between the two groups. Results: Although there was no significant difference in Fertilization rate (P=0. 67) between the DGC/Zeta and DGC groups, mean percentage of good Embryo Quality (P=0. 04), good blastocysts quality (P=0. 049), expanded blastocysts (P=0. 007), chemical pregnancies (P=0. 005) and clinical pregnancies (P=0. 007) were significantly higher in the DGC/ Zeta group compared to DGC. In addition, implantation rate was insignificantly higher in DGC/Zeta compared to DGC (P=0. 17). Conclusion: This is the second independent study showing combined DGC/Zeta procedure improves ICSI outcomes, especially the Pregnancy rate, compared to the classical DGC procedure and this is likely related to the improved quality of sperm selected by the DGC/Zeta procedure.

Cites

No record.

References

Cite

APA: Copy

KARIMI, Nazanin, MOHSENI KOUCHESFAHANI, HOMA, NASR ESFAHANI, MOHAMMAD HOSSEIN, TAVALAEE, MARZIYEH, SHAHVERDI, ABDOLHOSSEIN, & CHOOBINEH, HAMID. (2020). DGC/Zeta as A New Strategy to Improve Clinical Outcome in Male Factor Infertility Patients following Intracytoplasmic Sperm Injection: A Randomized, Single-Blind, Clinical Trial. CELL JOURNAL (YAKHTEH), 22(1), 55-59. SID. https://sid.ir/paper/731650/en

Vancouver: Copy

KARIMI Nazanin, MOHSENI KOUCHESFAHANI HOMA, NASR ESFAHANI MOHAMMAD HOSSEIN, TAVALAEE MARZIYEH, SHAHVERDI ABDOLHOSSEIN, CHOOBINEH HAMID. DGC/Zeta as A New Strategy to Improve Clinical Outcome in Male Factor Infertility Patients following Intracytoplasmic Sperm Injection: A Randomized, Single-Blind, Clinical Trial. CELL JOURNAL (YAKHTEH)[Internet]. 2020;22(1):55-59. Available from: https://sid.ir/paper/731650/en

IEEE: Copy

Nazanin KARIMI, HOMA MOHSENI KOUCHESFAHANI, MOHAMMAD HOSSEIN NASR ESFAHANI, MARZIYEH TAVALAEE, ABDOLHOSSEIN SHAHVERDI, and HAMID CHOOBINEH, “DGC/Zeta as A New Strategy to Improve Clinical Outcome in Male Factor Infertility Patients following Intracytoplasmic Sperm Injection: A Randomized, Single-Blind, Clinical Trial,” CELL JOURNAL (YAKHTEH), vol. 22, no. 1, pp. 55–59, 2020, [Online]. Available: https://sid.ir/paper/731650/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops