EFFICACY OF TERBINAFINE 1% CREAM VERSUS CLOTRIMAZOLE 1% CREAM IN THE TREATMENT OF PITYRIASIS VERSICOLOR

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REZVANI M.; SEFIDGAR S.A.A.

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Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2006 | Volume:8 | Issue:2 (30) Page(s): 42-46

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Title

EFFICACY OF TERBINAFINE 1% CREAM VERSUS CLOTRIMAZOLE 1% CREAM IN THE TREATMENT OF PITYRIASIS VERSICOLOR

Author(s)

REZVANI M. | SEFIDGAR S.A.A. | Issue Writer Certificate

Keywords

PITYRIASIS VERSICOLORQ3

FUNGAL INFECTIONQ3

TERBINAFINEQ3

CLOTRIMAZOLEQ3

Abstract

BACKGROUND AND OBJECTIVE: Terbinfine a member of allylamines group is a new class of antimycotic agents that blocks sterol biosynthesis in the fungi through inhibition of sequlene epoxidase and with consequent sequalene accumulation due to a primarily fungicidal process. TERBINAFINE is very effective on various fungi as an oral and topical antifungal agent. The aim of this study was to compare the antifungal efficacy of TERBINAFINE 1% cream with CLOTRIMAZOLE 1% in patients with PITYRIASIS VERSICOLOR. METHODS: This clinical trial study was performed on 50 patients (30 males and 20 females) with mean age of 20 years (aged between 15-55 years) who randomly treated with TERBINAFINE and CLOTRIMAZOLE for 4 weeks. The efficacy of drug and improving process evaluated mycologically and clinically before starting the study and at the end of each week. A patient was considered mycologically cured when direct microscopy was negative and clinically cured when all clinical parameters were considered negative. FINDINGS: Negativizations of all clinical parameters were observed within 2 weeks in 60% of terbinofine and 35% CLOTRIMAZOLE recipients. At the end of four weeks, disappear of lesions were seen in 90% and 80%, respectively (p<0.05). The percentage of negativization of direct microscopy in TERBINAFINE group was 1.4 fold higher than that CLOTRIMAZOLE group after 2 weeks of treatment. At the end of therapy, 95% of TERBINAFINE and 90% of CLOTRIMAZOLE treated subjects were clinically cured (p>0.05). Both drug eruptions and intolerance in two treated groups were similar. CONCLUSION: Although the efficacy of the both drugs is similar, but considering the expense of therapy, CLOTRIMAZOLE is preferred regimen for therapy of tinea versicolor.

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References

CLINICAL EFFICACY OF 1% TERBINAFINE CREAM (LAMIZIL)® IN COMPARISON TO 2% MICONAZOLE CREAM IN PATIENTS WITH PITYRIASIS VERSICOLOR

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APA: Copy

REZVANI, M., & SEFIDGAR, S.A.A.. (2006). EFFICACY OF TERBINAFINE 1% CREAM VERSUS CLOTRIMAZOLE 1% CREAM IN THE TREATMENT OF PITYRIASIS VERSICOLOR. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 8(2 (30)), 42-46. SID. https://sid.ir/paper/73217/en

Vancouver: Copy

REZVANI M., SEFIDGAR S.A.A.. EFFICACY OF TERBINAFINE 1% CREAM VERSUS CLOTRIMAZOLE 1% CREAM IN THE TREATMENT OF PITYRIASIS VERSICOLOR. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2006;8(2 (30)):42-46. Available from: https://sid.ir/paper/73217/en

IEEE: Copy

M. REZVANI, and S.A.A. SEFIDGAR, “EFFICACY OF TERBINAFINE 1% CREAM VERSUS CLOTRIMAZOLE 1% CREAM IN THE TREATMENT OF PITYRIASIS VERSICOLOR,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 8, no. 2 (30), pp. 42–46, 2006, [Online]. Available: https://sid.ir/paper/73217/en

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