مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

154
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

86
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess

Pages

  109-117

Abstract

 Statement of the Problem: Genetic Polymorphisms can alter immunity response against pathogens, which in turn influence individuals’ susceptibility to certain infec-tions. Purpose: Our aim was to determine the association of Arg753Gln (rs5743708) and Arg677Trp (rs12191786) Polymorphisms of Toll like receptor-2 gene with the two clinical forms of apical periodontitis: Acute apical abscess (AAA) and asymptomatic apical periodontitis (AAP). Materials and Method: There were 50 patients with AAA as case group and 50 with AAP as control group. Genotyping was done using Tetra-ARMS (amplification re-fractory mutation system) PCR. Results: Heterozygous genotype of Arg677Trp Polymorphism was associated with risk of AAA (OR=1. 9, 95% CI: 0. 7-5. 5, p= 0. 05). Although statistically insignificant, Arg677Trp Polymorphism promoted the risk of AAA in dominant model (OR=2. 1, 95% CI: 0. 7-5. 9, p> 0. 05). The frequency of mutant allele (T) of Arg677Trp poly-morphism was higher in AAA (14%) than AAP (7%) subjects (OR=1. 7, 95% CI: 0. 6-4. 7). For Arg753Gln Polymorphism, wild homozygous (GG) represented the domi-nant genotype in both cases (96%) and controls (100%). Variant allele (A) of Arg753Gln Polymorphism was identified in 2% of AAA, while no individual repre-sented with this allele in AAP subjects. Individuals with Arg753Gln; Arg677Trp (GG; TC) combination showed an elevated risk of AAA (OR=1. 6, 95% CI: 0. 5-4. 2, p> 0. 05). Conclusion: Arg677Trp Polymorphism of TLR-2 rendered a higher risk for the de-velopment of abscesses in apical periodontitis. It is recommended to explore role of this Polymorphism in other populations.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    MIRI MOGHADDAM, EBRAHIM, FARHAD MOLLASHAHI, NARGES, Naghibi, Nava, GARME, YASAMAN, & BAZI, ALI. (2018). Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 19(2), 109-117. SID. https://sid.ir/paper/733542/en

    Vancouver: Copy

    MIRI MOGHADDAM EBRAHIM, FARHAD MOLLASHAHI NARGES, Naghibi Nava, GARME YASAMAN, BAZI ALI. Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;19(2):109-117. Available from: https://sid.ir/paper/733542/en

    IEEE: Copy

    EBRAHIM MIRI MOGHADDAM, NARGES FARHAD MOLLASHAHI, Nava Naghibi, YASAMAN GARME, and ALI BAZI, “Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 19, no. 2, pp. 109–117, 2018, [Online]. Available: https://sid.ir/paper/733542/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button