Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury

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Ugurel Vedat; Cicek Ahmet Cagatay; Cemek Mustafa; DEMIRTAS SELIM; Kocaman A. Tuba; KARACA TURAN

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:1 Page(s): 53-58

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Title

Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury

Author(s)

Keywords

Antioxidant

Erdosteine

Ischemia-reperfusion

Oxidant

Ovary

Rat

Abstract

To evaluate the protective effect of Erdosteine, an antiapoptotic and Antioxidant agent, on torsion– detorsion evoked histopathological changes in experimental ovarian Ischemia-reperfusion (IR) injury. Materials and Methods: Eighteen female Wistar albino Rats were used in control, IR, and IR+Edosteine (IR-E) groups, (n=6 in each). The IR-E group received the Erdosteine for seven days before the induction of torsion/retorsion, (10 mg/kg/days). The IR and IR-E groups were exposed to right unilateral adnexal torsion for 3 hr. Three hours later, re-laparotomy was performed, and the right ovaries were surgically excised. Oxidant and Antioxidants levels were determined in serum. The ovarian tissue samples were received and fixed with 10% neutral buffered formalin. The sections were stained with H&E, anti-PCNA, and TUNEL. Results: The IR group were showed severe acute inflammation, polynuclear leukocytes and macrophages, stromal oedema and haemorrhage. Treatment with Erdosteine in Rats significantly retained degeneRative changes in the Ovary PCNA (+) cell numbers were significantly decreased in the IR and IR-E groups unlike the control group. However, its numbers were significantly increased in the IR-E group unlike the IR group. TUNEL (+) cell numbers were significantly increased in the IR group unlike the control and the IR-E groups. In Erdosteine treated group, TUNEL (+) cells were detected significantly less than the IR group (P<0. 05). Conclusion: In conclusion, Erdosteine maybe a protective agent for ovarian damage and decreasing lipid peroxidation products and leukocytes aggregation after adnexal torsion in animals.

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APA: Copy

Ugurel, Vedat, Cicek, Ahmet Cagatay, Cemek, Mustafa, DEMIRTAS, SELIM, Kocaman, A. Tuba, & KARACA, TURAN. (2017). Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(1), 53-58. SID. https://sid.ir/paper/733812/en

Vancouver: Copy

Ugurel Vedat, Cicek Ahmet Cagatay, Cemek Mustafa, DEMIRTAS SELIM, Kocaman A. Tuba, KARACA TURAN. Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(1):53-58. Available from: https://sid.ir/paper/733812/en

IEEE: Copy

Vedat Ugurel, Ahmet Cagatay Cicek, Mustafa Cemek, SELIM DEMIRTAS, A. Tuba Kocaman, and TURAN KARACA, “Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 1, pp. 53–58, 2017, [Online]. Available: https://sid.ir/paper/733812/en

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