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Information Journal Paper

Title

Depression was associated with apolipoprotein E ε 4 allele polymorphism: A meta-analysis

Pages

  112-117

Abstract

 Objective(s): Previous studies have reached different conclusions regarding an association between Apolipoprotein E (APOE) Polymorphisms and Depression. This Meta-analysis was designed to clarify these controversies. Materials and Methods: Literatures were identified reviewing the national and international databases. The eligible articles for Meta-analysis were determined by quality assessment and implementation of inclusion/ exclusion criteria. This Meta-analysis was performed using Review Manager 5. 2 software. The odds ratios (ORs) with corresponding 95% confidence interval (CIs) were calculated using a fixed effects model. Funnel plots and Egger’ s regression tests were used to assess the publication bias. Results: A total of nine studies that met the inclusion criteria were identified by performing a comprehensive search on the association between APOE Polymorphisms and Depression. APOE ε 4 allele was significantly associated with Depression (allele: OR=1. 36, 95%CI=1. 11-1. 66, P=0. 003; dominant: OR=1. 34, 95%CI=1. 06-1. 68, P=0. 001; recessive: OR= 1. 11, 95%CI =0. 45-2. 76, P=0. 82). HAMD scores were higher in Depression patients with-APOE ε 4 genotype than who without-APOE ε 4 genotype (OR=0. 96, 95%CI=0. 16-1. 76, P=0. 02). Conclusion: APOE ε 4 allele increased the Depression risk; depressive patients carrying APOE ε 4 allele had more severe depressive symptoms.

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    APA: Copy

    WANG, WEI WEI, Liu, Xiao lei, Ruan, Ye, WANG, LIN, & Bao, Tian Hao. (2019). Depression was associated with apolipoprotein E ε 4 allele polymorphism: A meta-analysis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(2), 112-117. SID. https://sid.ir/paper/734198/en

    Vancouver: Copy

    WANG WEI WEI, Liu Xiao lei, Ruan Ye, WANG LIN, Bao Tian Hao. Depression was associated with apolipoprotein E ε 4 allele polymorphism: A meta-analysis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(2):112-117. Available from: https://sid.ir/paper/734198/en

    IEEE: Copy

    WEI WEI WANG, Xiao lei Liu, Ye Ruan, LIN WANG, and Tian Hao Bao, “Depression was associated with apolipoprotein E ε 4 allele polymorphism: A meta-analysis,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 2, pp. 112–117, 2019, [Online]. Available: https://sid.ir/paper/734198/en

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