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Information Journal Paper

Title

Mesenchymal stem cells that located in the electromagnetic fields improves rat model of Parkinson's disease

Pages

  741-748

Abstract

 Objective(s): The main characteristic of Mesenchymal stem cells (MSCs) is their ability to produce other cell types. Electromagnetic field (EMF) stimulates differentiation of MSCs into other cells. In this study, we investigated whether EMF can effect on the differentiation of MSCs into dopaminergic (DA) neurons. Materials and Methods: An EMF with a frequency of 50 Hz and two intensities of 40 and 400 μ T 1hr/day was generated around the cells for a week. Afterwards, these cells were injected into the left ventricle of Parkinsonian rats. The rats survived for 2 weeks, and then sampling was performed. Results: The injected cells differentiated into DA neurons and sporadically settled in the substantia nigra pars compacta (SNpc). Transplanted rats exhibited significant partial correction apomorphine-induced rotational behavior compared to Parkinsonian rats (5. 0± 0. 1 vs 7. 57± 0. 08). Results demonstrated that endogenous serum and brain derived neurotrophic factor (BDNF) were altered in all experimental groups. The greatest increase was in group of 400 μ T EMF in comparison with Parkinsonian rats (398± 15 vs. 312± 11. 79 pg ⁄ mg). Current study have shown that 6-Hydroxydopamine can cause severe loss of Dopaminergic neurons (68± 6. 58), but injected MSCs that exposed to 40 and 400 μ T EMF increased Dopaminergic neurons in SNpc ( 108± 2. 33 & 126± 3. 89) (P<0. 001). Conclusion: Electromagnetic fields with particular frequencies stimulate MSCs. So, these cells had anti-Parkinsonian properties in our studies.

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    APA: Copy

    JADIDI, MAJID, Moghadas Biat, Saeed, SAMENI, HAMID REZA, SAFARI, MANOUCHEHR, VAFAEI, ABBAS ALI, & GHAHARI, LAYA. (2016). Mesenchymal stem cells that located in the electromagnetic fields improves rat model of Parkinson's disease. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(7), 741-748. SID. https://sid.ir/paper/734201/en

    Vancouver: Copy

    JADIDI MAJID, Moghadas Biat Saeed, SAMENI HAMID REZA, SAFARI MANOUCHEHR, VAFAEI ABBAS ALI, GHAHARI LAYA. Mesenchymal stem cells that located in the electromagnetic fields improves rat model of Parkinson's disease. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(7):741-748. Available from: https://sid.ir/paper/734201/en

    IEEE: Copy

    MAJID JADIDI, Saeed Moghadas Biat, HAMID REZA SAMENI, MANOUCHEHR SAFARI, ABBAS ALI VAFAEI, and LAYA GHAHARI, “Mesenchymal stem cells that located in the electromagnetic fields improves rat model of Parkinson's disease,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 7, pp. 741–748, 2016, [Online]. Available: https://sid.ir/paper/734201/en

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