مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CX691, as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer’ s disease

Pages

  724-730

Abstract

 Objective(s): Growing evidence suggests that dysfunction of the glutamatergic system and α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptors are involved in pathology of Alzheimer’ s disease (AD). Because AMPA receptors play a key role in plasticity synaptic regulation, positive modulation of these receptors may rescue the cognitive deficits in the AD. The aim of this study was to explore the effect of CX691, a specific positive allosteric modulator of the AMPA-type glutamate receptors (Ampakine), on spatial learning and Memory in a Rat model of AD. Materials and Methods: For induction of AD, amyloid-beta 1-42 (Aβ 1-42) was microinjected into the hippocampus of male Wistar Rats (250-300 g). The Morris water maze (MWM) test was used to evaluate the effect of CX691 (0. 03 and 0. 3 mg/kg, twice a day for 10 days, orally) on spatial learning and Memory of Rats. In order to evaluate the protein expression of brain-derived neurotrophic factor (BDNF) in hippocampus tissue, ELISA test was used. Results: The obtained data showed that treatment with CX691 (0. 3 mg/kg) improves the impairment of spatial learning and Memory in AD Rats. Also, treatment with CX691 (0. 3 mg/kg), increased the BDNF protein level in hippocampus tissue of AD Rats compared to non-treated animals. Conclusion: The CX691 can improve the BDNF protein expression as well as spatial performance of learning and Memory in AD Rats.

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    Cite

    APA: Copy

    Mozafari, Nazanin, SHAMSIZADEH, ALI, FATEMI, IMAN, ALLAHTAVAKOLI, MOHAMMAD, MOGHADAM AHMADI, AMIR, Kaviani, Elham, & KAEIDI, AYAT. (2018). CX691, as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer’ s disease. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(7), 724-730. SID. https://sid.ir/paper/734216/en

    Vancouver: Copy

    Mozafari Nazanin, SHAMSIZADEH ALI, FATEMI IMAN, ALLAHTAVAKOLI MOHAMMAD, MOGHADAM AHMADI AMIR, Kaviani Elham, KAEIDI AYAT. CX691, as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer’ s disease. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(7):724-730. Available from: https://sid.ir/paper/734216/en

    IEEE: Copy

    Nazanin Mozafari, ALI SHAMSIZADEH, IMAN FATEMI, MOHAMMAD ALLAHTAVAKOLI, AMIR MOGHADAM AHMADI, Elham Kaviani, and AYAT KAEIDI, “CX691, as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer’ s disease,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 7, pp. 724–730, 2018, [Online]. Available: https://sid.ir/paper/734216/en

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