مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

237
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

200
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver

Pages

  499-505

Abstract

 Objective(s): Recognized as a distinguished environmental and global toxicant, Bisphenol A (BPA) affects the Liver, which is a vital body organ, by the induction of Oxidative stress. The present study was designed to investigate the protective effect of Quercetin against BPA in hepatotoxicity in Wistar rats and also, the activity of Mitochondrial enzymes were evaluated. Materials and Methods: To this end, 32 male Wistar rats were divided into four groups (six rats per group), including control, BPA (250 mg/kg), BPA + Quercetin (75 mg/kg), and Quercetin (75 mg/kg). Results: The BPA-induced alterations were restored in concentrations of alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) due to the Quercetin treatment (75 mg/kg) (all P<0. 001). While the levels of Mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and malondialdehyde (MDA) decreased by the Quercetin treatment in the Liver Mitochondria (P<0. 001), catalase (CAT) and glutathione (GSH) increased (P<0. 001). Conclusion: According to the results, the potential hepatotoxicity of BPA can be prevented by Quercetin, which protects the body against Oxidative stress and BPA-induced biochemical toxicity. Moreover, the reproductive toxicity of BPA after environmental or occupational exposures can be potentially prohibited by Quercetin.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    MAHDAVINIA, MASOUD, ALIZADEH, SAID, RAESI VANANI, ATEFEH, DEHGHANI, MOHAMMAD AMIN, SHIRANI, MARYAM, ALIPOUR, MEYSAM, Shahmohammadi, Hedayat Allah, & Rafiei Asl, Sirous. (2019). Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(5), 499-505. SID. https://sid.ir/paper/734290/en

    Vancouver: Copy

    MAHDAVINIA MASOUD, ALIZADEH SAID, RAESI VANANI ATEFEH, DEHGHANI MOHAMMAD AMIN, SHIRANI MARYAM, ALIPOUR MEYSAM, Shahmohammadi Hedayat Allah, Rafiei Asl Sirous. Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(5):499-505. Available from: https://sid.ir/paper/734290/en

    IEEE: Copy

    MASOUD MAHDAVINIA, SAID ALIZADEH, ATEFEH RAESI VANANI, MOHAMMAD AMIN DEHGHANI, MARYAM SHIRANI, MEYSAM ALIPOUR, Hedayat Allah Shahmohammadi, and Sirous Rafiei Asl, “Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 5, pp. 499–505, 2019, [Online]. Available: https://sid.ir/paper/734290/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button