The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AKBARI KORDKHEYLI VAHID; Abbaszadeh Goudarzi Kazem; Nejati Laskokalayeh Mohaddeseh; ZARPOU SETAREH; KHONAKDAR TARSI ABBAS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:9 Page(s): 965-976

Download Full-Text

View:

293

Download:

157

Cites:

Information Journal Paper

Title

The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review

Author(s)

Keywords

Inflammation

Ischemia

Oxidative stress

Reperfusion

Silymarin

Abstract

Ischemia-Reperfusion injuries (IRI) occur in different clinical conditions such as stroke, trauma, organ transplantation, and so on. Ischemia damages mainly arise from oxygen depletion in tissues. The lack of oxygen as the last acceptor of electron in the respiratory chain causes a decrease in ATP production and eventually leads to disruption of membrane transport, acidosis, cellular edema and membrane distortion of organelles, and cells. Reperfusion can intensify ischemic injuries by the infiltration of inflammatory cells and also oxygen and calcium overloading. Since the tissue antioxidant contents decreased due to increased generation of reactive oxygen species (ROS) during IRI, the application of antioxidants is considered an appropriate strategy to ameliorate IRI. Silymarin constitutes about 70– 80% of silybum marianum dry extract and is known as a strong free radical scavenger with anti-inflammatory properties. In several studies, silibinin as a major component of Silymarin could provide protective effects in various tissue IRI by different mechanisms such as scavenging free radicals, decreasing inflammatory cytokines, inhibiting cellular death, and increasing the expression of antioxidant enzymes. To clarify functional mechanisms, the present article evaluates studies about Silymarin effects in different tissues IRI.

Cites

Effect of Oral Administration of Silymarin on Healing Full-thickness Gastric Wound in Rats

References

Cite

APA: Copy

AKBARI KORDKHEYLI, VAHID, Abbaszadeh Goudarzi, Kazem, Nejati Laskokalayeh, Mohaddeseh, ZARPOU, SETAREH, & KHONAKDAR TARSI, ABBAS. (2019). The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(9), 965-976. SID. https://sid.ir/paper/734713/en

Vancouver: Copy

AKBARI KORDKHEYLI VAHID, Abbaszadeh Goudarzi Kazem, Nejati Laskokalayeh Mohaddeseh, ZARPOU SETAREH, KHONAKDAR TARSI ABBAS. The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(9):965-976. Available from: https://sid.ir/paper/734713/en

IEEE: Copy

VAHID AKBARI KORDKHEYLI, Kazem Abbaszadeh Goudarzi, Mohaddeseh Nejati Laskokalayeh, SETAREH ZARPOU, and ABBAS KHONAKDAR TARSI, “The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 9, pp. 965–976, 2019, [Online]. Available: https://sid.ir/paper/734713/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops