Toxin profiles and antimicrobial resistance patterns among toxigenic clinical isolates of Clostridioides (Clostridium) difficile

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HEIDARI HAMID; SEDIGH EBRAHIM SARAIE HADI; AMANATI ALI; MOTAMEDIFAR MOHAMMAD; HADI NAHAL; BAZARGANI ABDOLLAH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:7 Page(s): 813-819

Download Full-Text

View:

280

Download:

113

Cites:

Information Journal Paper

Title

Toxin profiles and antimicrobial resistance patterns among toxigenic clinical isolates of Clostridioides (Clostridium) difficile

Author(s)

Keywords

Antibiotic resistance

CDT

Clostridioides (Clostridium)-difficile

C-difficile infection

Toxins

Abstract

Objective(s): Clostridioides (Clostridium) difficile infection as a healthcare-associated infection can cause life-threatening infectious diarrhea in hospitalized patients. The aim of this study was to investigate the toxin profiles and antimicrobial resistance patterns of C. difficile isolates obtained from hospitalized patients in Shiraz, Iran. Materials and Methods: This study was performed on 45 toxigenic C. difficile isolates. Determination of toxin profiles was done using polymerase chain reaction method. Antimicrobial susceptibility to vancomycin, metronidazole, clindamycin, tetracycline, moxifloxacin, and chloramphenicol was determined by the agar dilution method. The genes encoding Antibiotic resistance were detected by the standard procedures. Results: The most frequent toxin profile was tcdA+, tcdB+, CDTAˉ , CDTBˉ (82. 2%), and only one isolate harboured all toxin associated genes (tcdA+, tcdB+, CDTA+, CDTB+) (2. 2%). The genes encoding CDT (binary toxin) were also found in six (13. 3%) isolates. Resistance to tetracycline, clindamycin and moxifloxacin was observed in 66. 7%, 60% and 42. 2% of the isolates, respectively. None of the strains showed resistance to other antibiotics. The distribution of the ermB gene (the gene encoding resistance to clindamycin) was 57. 8% and the tetM and tetW genes (the genes encoding resistance to tetracycline) were found in 62. 2% and 13. 3% of the isolates, respectively. The substitutions Thr82 to Ile in GyrA and Asp426 to Asn in GyrB were seen in moxifloxacin resistant isolates. Conclusion: Our data contributes to the present understanding of virulence and resistance traits amongst the isolates. Infection control strategies should be implemented carefully in order to curb the dissemination of C. difficile strains in hospital.

Cites

No record.

References

Cite

APA: Copy

HEIDARI, HAMID, SEDIGH EBRAHIM SARAIE, HADI, AMANATI, ALI, MOTAMEDIFAR, MOHAMMAD, HADI, NAHAL, & BAZARGANI, ABDOLLAH. (2019). Toxin profiles and antimicrobial resistance patterns among toxigenic clinical isolates of Clostridioides (Clostridium) difficile. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(7), 813-819. SID. https://sid.ir/paper/735155/en

Vancouver: Copy

HEIDARI HAMID, SEDIGH EBRAHIM SARAIE HADI, AMANATI ALI, MOTAMEDIFAR MOHAMMAD, HADI NAHAL, BAZARGANI ABDOLLAH. Toxin profiles and antimicrobial resistance patterns among toxigenic clinical isolates of Clostridioides (Clostridium) difficile. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(7):813-819. Available from: https://sid.ir/paper/735155/en

IEEE: Copy

HAMID HEIDARI, HADI SEDIGH EBRAHIM SARAIE, ALI AMANATI, MOHAMMAD MOTAMEDIFAR, NAHAL HADI, and ABDOLLAH BAZARGANI, “Toxin profiles and antimicrobial resistance patterns among toxigenic clinical isolates of Clostridioides (Clostridium) difficile,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 7, pp. 813–819, 2019, [Online]. Available: https://sid.ir/paper/735155/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops