SENSITIVITY AND SPECIFICITY OF P16 IMMUNOHISTOCHEMISTRY IN DIAGNOSIS OF DYSPLASTIC NEOPLASTIC CHANGES IN CERVIX

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHARBATDARAN M.; SHAFAEI SH.; ZEYNALZADEH MAHTAB; RANJBAR H.; JAHED B.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Babol University of Medical Sciences Year:2009 | Volume:11 | Issue:1 (48) Page(s): 8-13

Download Full-Text

Persian Verion

View:

1,552

Download:

Cites:

Information Journal Paper

Title

SENSITIVITY AND SPECIFICITY OF P16 IMMUNOHISTOCHEMISTRY IN DIAGNOSIS OF DYSPLASTIC NEOPLASTIC CHANGES IN CERVIX

Author(s)

Keywords

SENSITIVITYQ3

SPECIFICITYQ3

UTERINE CERVICAL DYSPLASIAQ3

METAPLASIAQ3

UTERINE CERVICAL NEOPLASMQ3

CERVICAL INTRAEPITHELIAL NEOPLASIAQ3

CYCLINE DEPENDENT KINASE INHIBITOR P16Q3

Abstract

BACKGROUND AND OBJECTIVE: Cervical cancer is the second most common cancer in women that early diagnosis of its preneoplastic lesion can reduce cancer development. The aim of this study was to evaluate P16 role as a biomarker in diagnosis of dysplastic and neoplastic lesions of uterine cervix with immunohistochemistry.METHODS: This study was done on samples of 96 women in pathology department of Shahid Yahyanejad hospital, Babol, Iran. The samples divided into 4 groups (30 cases of normal cervix, 30 cases of cervical immature METAPLASIA, 30 cases of cervical dysplasia and 6 cases of cervical malignancy of squamous cell type).Immunohistochemical method was performed using kit of Dako company, made in Denmark, (p16INK4a, Clone E6H4), on paraffin embedded samples. P16 staining results, histopathological findings and age of women were analyzed and compared.FINDINGS: P16 staining was positive in 10% of normal cervix (3 subjects), 30% of cervical immature METAPLASIA (9 subjects), 63.3% of cervical dysplasia (19 subjects) and 83.3% of normal cervix (5 subjects). In cases with dysplasia P16 was positive in 4 subjects of grade I, 8 subjects of grade II and 7 subjects of grade III that there was not a significant relationship. The SENSITIVITY of P16 was 83.3% in uterine cervical squamous cancer and SENSITIVITY was respectively 63.3% in dysplasia and 30% in immature squamous METAPLASIA. The SPECIFICITY of P16 was 80%.CONCLUSION: Result show that P16 had suitable SENSITIVITY and SPECIFICITY for diagnosis of dysplasia and neoplasia of uterine cervix and can be used in diagnosis of cancer lesions.

Cites

No record.

References

Cite

APA: Copy

SHARBATDARAN, M., SHAFAEI, SH., ZEYNALZADEH, MAHTAB, RANJBAR, H., & JAHED, B.. (2009). SENSITIVITY AND SPECIFICITY OF P16 IMMUNOHISTOCHEMISTRY IN DIAGNOSIS OF DYSPLASTIC NEOPLASTIC CHANGES IN CERVIX. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 11(1 (48)), 8-13. SID. https://sid.ir/paper/73527/en

Vancouver: Copy

SHARBATDARAN M., SHAFAEI SH., ZEYNALZADEH MAHTAB, RANJBAR H., JAHED B.. SENSITIVITY AND SPECIFICITY OF P16 IMMUNOHISTOCHEMISTRY IN DIAGNOSIS OF DYSPLASTIC NEOPLASTIC CHANGES IN CERVIX. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2009;11(1 (48)):8-13. Available from: https://sid.ir/paper/73527/en

IEEE: Copy

M. SHARBATDARAN, SH. SHAFAEI, MAHTAB ZEYNALZADEH, H. RANJBAR, and B. JAHED, “SENSITIVITY AND SPECIFICITY OF P16 IMMUNOHISTOCHEMISTRY IN DIAGNOSIS OF DYSPLASTIC NEOPLASTIC CHANGES IN CERVIX,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 11, no. 1 (48), pp. 8–13, 2009, [Online]. Available: https://sid.ir/paper/73527/en

Related Journal Papers