مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

268
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

191
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

met1 DNA Methyltransferase Controls TERT Gene Expression: A New Insight to The Role of Telomerase in Development

Author(s)

 ZANGI MARYAM | BAGHERIEH NAJJAR MOHAMMAD BAGHER | GOLALIPOUR MASOUD | AGHDASI MAHNAZ | Issue Writer Certificate 

Pages

  71-74

Abstract

 Objective: DNA methylation systems are essential for proper embryo development. Methylation defects lead to Developmental Abnormalities. Furthermore, changes in Telomerase gene expression can affect stability of chromosomes and produces abnormal growth. Therefore, defects in both methylation and Telomerase gene expression can lead to Developmental Abnormalities. We hypothesized that mutation in the methylation systems may induce Developmental Abnormalities through changing Telomerase gene expression. Materials and Methods: In this experimental study, we used Arabidopsis thaliana (At) as a developmental model. DNA was extracted from seedlings leaves. The grown plants were screened using polymerase chain reaction (PCR) reactions. Total RNA was isolated from the mature leaves, stems and flowers of wild type and met1 mutants. For gene expression analysis, cDNA was synthesized and then quantitative reverse transcription PCR (qRT-PCR) was performed. Results: Telomerase gene expression level in homozygous met1 mutant plants showed ~14 fold increase compared to normal plants. Furthermore, TERT expression in met1 heterozygous was~ 2 fold higher than the wild type plants. Conclusion: Our results suggested that TERT is a methyltransferase-regulated gene which may be involved in developmental abnormities causing by mutation in met1 methyltransferase system.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    ZANGI, MARYAM, BAGHERIEH NAJJAR, MOHAMMAD BAGHER, GOLALIPOUR, MASOUD, & AGHDASI, MAHNAZ. (2020). met1 DNA Methyltransferase Controls TERT Gene Expression: A New Insight to The Role of Telomerase in Development. CELL JOURNAL (YAKHTEH), 22(1), 71-74. SID. https://sid.ir/paper/735474/en

    Vancouver: Copy

    ZANGI MARYAM, BAGHERIEH NAJJAR MOHAMMAD BAGHER, GOLALIPOUR MASOUD, AGHDASI MAHNAZ. met1 DNA Methyltransferase Controls TERT Gene Expression: A New Insight to The Role of Telomerase in Development. CELL JOURNAL (YAKHTEH)[Internet]. 2020;22(1):71-74. Available from: https://sid.ir/paper/735474/en

    IEEE: Copy

    MARYAM ZANGI, MOHAMMAD BAGHER BAGHERIEH NAJJAR, MASOUD GOLALIPOUR, and MAHNAZ AGHDASI, “met1 DNA Methyltransferase Controls TERT Gene Expression: A New Insight to The Role of Telomerase in Development,” CELL JOURNAL (YAKHTEH), vol. 22, no. 1, pp. 71–74, 2020, [Online]. Available: https://sid.ir/paper/735474/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button