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Information Journal Paper

Title

Comparison of The Expression of miR-326 between Interferon beta Responders and Non-Responders in Relapsing-Remitting Multiple Sclerosis

Author(s)

 Fattahi Mahtab | ESKANDARI NAHID | SOTOODEHNEJAD NEMATALAHI FATTAH | SHAYGANNEJAD VAHID | KAZEMI MOHAMMAD | Issue Writer Certificate 

Pages

  92-95

Abstract

 Objective: Multiple Sclerosis (MS) is an inflammatory disease resulting in demyelination of the central nervous system (CNS). T helper 17 (Th17) subset protects the human body against pathogens and induces neuroinflammation, which leads to neurodegeneration. MicroRNAs (miRNAs) are a specific class of small (~22 nt) non-coding RNAs that act as post-transcriptional regulators. The expression of the miR-326 is highly associated with the pathogenesis of MS disease in patients through the promotion of Th17 development. Recently, studies showed that disease-modifying therapies (DMTs) could balance the dysregulation of miRNAs in the immune cells of patients with relapsing-remitting MS (RRMS). Interferon-Beta (IFN-β ) has emerged as one of the most common drugs for the treatment of RR-MS patients. The purpose of this study was to evaluate the expression of the miR-326 in RRMS patients who were responders and nonresponders to IFN-β treatment. Materials and Methods: In this cross-sectional study, a total of 70 patients (35 responders and 35 non-responders) were enrolled. We analyzed the expression of the miR-326 in peripheral blood mononuclear cells (PBMCs) of RRMS patients at least one year after the initiation of IFN-β therapy. Real-time polymerase chain reaction (RT-PCR) was applied to measure the expression of the miR-326. Results: The results showed no substantial change in the expression of the miR-326 between responders and nonresponders concerning the treatment with IFN-β . Although the expression of the miR-326 was slightly reduced in IFN-β-responders compared with IFN-β-non-responders; however, the reduction of the miR-326 was not statistically significant. Conclusion: Overall, since IFN-β doesn’ t normalize abnormal expression of miR-326, this might suggest that IFN-β affects Th17 development through epigenetic mechanisms other than miR-326 regulation.

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    Cite

    APA: Copy

    Fattahi, Mahtab, ESKANDARI, NAHID, SOTOODEHNEJAD NEMATALAHI, FATTAH, SHAYGANNEJAD, VAHID, & KAZEMI, MOHAMMAD. (2020). Comparison of The Expression of miR-326 between Interferon beta Responders and Non-Responders in Relapsing-Remitting Multiple Sclerosis. CELL JOURNAL (YAKHTEH), 22(1), 92-95. SID. https://sid.ir/paper/735475/en

    Vancouver: Copy

    Fattahi Mahtab, ESKANDARI NAHID, SOTOODEHNEJAD NEMATALAHI FATTAH, SHAYGANNEJAD VAHID, KAZEMI MOHAMMAD. Comparison of The Expression of miR-326 between Interferon beta Responders and Non-Responders in Relapsing-Remitting Multiple Sclerosis. CELL JOURNAL (YAKHTEH)[Internet]. 2020;22(1):92-95. Available from: https://sid.ir/paper/735475/en

    IEEE: Copy

    Mahtab Fattahi, NAHID ESKANDARI, FATTAH SOTOODEHNEJAD NEMATALAHI, VAHID SHAYGANNEJAD, and MOHAMMAD KAZEMI, “Comparison of The Expression of miR-326 between Interferon beta Responders and Non-Responders in Relapsing-Remitting Multiple Sclerosis,” CELL JOURNAL (YAKHTEH), vol. 22, no. 1, pp. 92–95, 2020, [Online]. Available: https://sid.ir/paper/735475/en

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