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Information Journal Paper

Title

The effect of resveratrol on expression of matrix metalloproteinase 9 and its tissue inhibitors in vascular smooth muscle cells

Pages

  157-162

Abstract

 BACKGROUND: Matrix Metalloproteinase 9 (MMP-9) is involved in extracellular matrix degradation and remodeling. An increase in MMP-9 expression by vascular component cells plays an important role in atherosclerotic plaque formation and rupture. Resveratrol, a polyphenolic substance, was suggested to play a role in preventing the progress of atherosclerotic disease. The aim of this study was to investigate the effect of Resveratrol on MMP-9 and tissue inhibitors of metalloproteinases (TIMPS) in Vascular Smooth Muscle cells (VSMCs) after treatment with H2O2. METHODS: Cultured VSMCs were pre-treated with 0. 2 mM of H2O2 before stimulation with different concentration of Resveratrol. Expression of MMP-9, TIMP-1, and TIMP-3 genes were measured using real-time polymerase chain reaction (PCR) method, and MMP-9 protein level was detected using western blot analysis. RESULTS: Resveratrol at 120 μ mol/l concentration reduced the elevated level of MMP-9 induced by H2O2 in VSMCs as 1. 85 ± 0. 35 folds (P < 0. 05) and 8. 70 ± 1. 20 folds (P < 0. 05) after 24 and 48 hours, respectively. Resveratrol increased the diminished level of TIMP-1 induced by H2O2 as 2. 5 ± 0. 48 folds following the treatment with 120 μ mol/l after 48 hours (P < 0. 05). CONCLUSION: Resveratrol as an antioxidant can decrease MMP-9 production, not only by suppressing MMP-9 expression, but also by augmenting TIMP-1 production. Altogether, Resveratrol as an antioxidant can regulate the MMP-9/TIMP-1 balance, and may be considered as a preservative agent in the treatment and prevention of atherosclerosis.

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    Cite

    APA: Copy

    FARROKHI, EFFAT, GHATREH SAMANI, KEIHAN, Salehi Vanani, Najmeh, & MAHMOODI, AMIN. (2018). The effect of resveratrol on expression of matrix metalloproteinase 9 and its tissue inhibitors in vascular smooth muscle cells. ARYA ATHEROSCLEROSIS, 14(4), 157-162. SID. https://sid.ir/paper/735864/en

    Vancouver: Copy

    FARROKHI EFFAT, GHATREH SAMANI KEIHAN, Salehi Vanani Najmeh, MAHMOODI AMIN. The effect of resveratrol on expression of matrix metalloproteinase 9 and its tissue inhibitors in vascular smooth muscle cells. ARYA ATHEROSCLEROSIS[Internet]. 2018;14(4):157-162. Available from: https://sid.ir/paper/735864/en

    IEEE: Copy

    EFFAT FARROKHI, KEIHAN GHATREH SAMANI, Najmeh Salehi Vanani, and AMIN MAHMOODI, “The effect of resveratrol on expression of matrix metalloproteinase 9 and its tissue inhibitors in vascular smooth muscle cells,” ARYA ATHEROSCLEROSIS, vol. 14, no. 4, pp. 157–162, 2018, [Online]. Available: https://sid.ir/paper/735864/en

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