EFFECT OF ERYTHROMYCIN ON THE INTESTINAL TRANSPORT OF CYCLOSPORINE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZAKERI MILANI P.; DAMANI S.; ESLAMBOULCHILAR Z.; MEHTARI M.; VALIZADEH H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2009 | Volume:11 | Issue:2 (49) Page(s): 7-15

Download Full-Text

Persian Verion

View:

973

Download:

Cites:

Information Journal Paper

Title

EFFECT OF ERYTHROMYCIN ON THE INTESTINAL TRANSPORT OF CYCLOSPORINE

Author(s)

Keywords

TRANSPORTQ3

ERYTHROMYCINQ3

PERFUSIONQ3

EFFLUX PUMPQ3

CYCLOSPORINEQ3

Abstract

BACKGROUND AND OBJECTIVE: Co-administration of CYCLOSPORINE and ERYTHROMYCIN can cause nephrotoxicity which could be a result of interaction in absorption and/or metabolism level. The purpose of this work was to investigate the interaction of ERYTHROMYCIN and CYCLOSPORINE in absorption level to evaluate the effect of ERYTHROMYCIN on CYCLOSPORINE absorption quantitatively. The stability of drug at 37oC and its adsorption to plastic syringe and tubes were also investigated.METHODS: 32 Wistar rats weighting between 200-300 g were used in the present study. They were divided into 4 test groups and 4 control groups. A jejunal segment of anaesthetized rat was cannulated and perfused by concentrations of 20, 15, 10 and 5 micromolar of drug in the presence and absence of 150 micromolar ERYTHROMYCIN by flow rate of 0.2 ml/min. Samples were obtained up to 90 min. Drug concentrations were assayed in different time points. The drug effective permeability values were calculated for its different concentrations in different experiments. A reverse-phase HPLC method was used for analysis of all samples.FINDINGS: The CYCLOSPORINE effective permeability values were increased from 22.1-33.4 (´10-6) cm/sec in control group to 37.2-53.4 (´10-6) cm/sec in test group that this difference was significant (p<0.05). Moreover CYCLOSPORINE was stable and only 4-5% loss of drug was observed at the end of experiment. However there was a significant adsorption of drug to syringe and tubing.CONCLUSION: Based on obtained results CYCLOSPORINE is a low solubility and high permeability drug. At least some part of clinical interaction between CYCLOSPORINE and ERYTHROMYCIN is due to interaction in absorption level.

Cites

No record.

References

No record.

Cite

APA: Copy

ZAKERI MILANI, P., DAMANI, S., ESLAMBOULCHILAR, Z., MEHTARI, M., & VALIZADEH, H.. (2009). EFFECT OF ERYTHROMYCIN ON THE INTESTINAL TRANSPORT OF CYCLOSPORINE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 11(2 (49)), 7-15. SID. https://sid.ir/paper/73603/en

Vancouver: Copy

ZAKERI MILANI P., DAMANI S., ESLAMBOULCHILAR Z., MEHTARI M., VALIZADEH H.. EFFECT OF ERYTHROMYCIN ON THE INTESTINAL TRANSPORT OF CYCLOSPORINE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2009;11(2 (49)):7-15. Available from: https://sid.ir/paper/73603/en

IEEE: Copy

P. ZAKERI MILANI, S. DAMANI, Z. ESLAMBOULCHILAR, M. MEHTARI, and H. VALIZADEH, “EFFECT OF ERYTHROMYCIN ON THE INTESTINAL TRANSPORT OF CYCLOSPORINE,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 11, no. 2 (49), pp. 7–15, 2009, [Online]. Available: https://sid.ir/paper/73603/en

Related Journal Papers