Analgesic Efficacy of Intravenous Lidocaine Infusion in Cesarean Section under Spinal Anesthesia: A Prospective Randomized Double-Blind Study

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BEIGOM KHEZRI MARZIEH; RAJABI MARYAM; YAGHOOBI SIAMAK; PAKNIAT HAMIDEH

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Journal Paper

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Journal: Journal of Advances in Medical and Biomedical Research Year:2019 | Volume:27 | Issue:123 Page(s): 31-37

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Title

Analgesic Efficacy of Intravenous Lidocaine Infusion in Cesarean Section under Spinal Anesthesia: A Prospective Randomized Double-Blind Study

Author(s)

BEIGOM KHEZRI MARZIEH | RAJABI MARYAM | YAGHOOBI SIAMAK | PAKNIAT HAMIDEH | Issue Writer Certificate

Keywords

Anesthesia

Cesarean section

Pain

Lidocaine

Spinal

Abstract

Background & Objective: Nowadays, conventional analgesic agents that are usually used for Pain killing after Cesarean sections do not provide enough analgesia with infrequent serious side effects. Lidocaine has been suggested as an adjuvant analgesic agent for postoperative Pain relief. We designed this randomized double-blind, placebo-controlled study to evaluate the analgesic efficacy of intravenous Lidocaine in patients undergoing a Cesarean section under Spinal Anesthesia. Materials & Methods: Eighty patients undergoing elective Cesarean section under Spinal Anesthesia were randomly divided into two groups to receive intravenous 1. 5 mg/kg of Lidocaine 2% bolus 15 minutes prior to Spinal Anesthesia followed by an intravenous infusion of 1. 5 mg/kg/h for 60 minutes (L group) or 0. 9% sodium chloride (C group) in a double-blind fashion. The time until the first request for an analgesic, the duration of sensory and motor blockade, hemodynamic variables and adverse events were recorded. Results: The difference in sensory (95% CI 10. 18 to 18. 01; P≤ 0. 001) and motor (95% CI 35. 50 to 50. 19; P≤ 0. 001) blockade durations between groups L and C were significant. Similarly, the mean time until the first analgesic request was longer in group L (175. 37± 21. 43) than in group C (157. 12± 15. 25); the difference between the two groups was significant (95% CI9. 95 to 26. 54; P<0. 001). Conclusion: Intravenous Lidocaine given as a supplementary agent in patients undergoing Cesarean section under Spinal Anesthesia prolonged the duration of the sensory and motor blockade of Spinal Anesthesia and delayed the first analgesic request by patients without hemodynamic disturbance, respiratory depression and compromising the fetus.

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APA: Copy

BEIGOM KHEZRI, MARZIEH, RAJABI, MARYAM, YAGHOOBI, SIAMAK, & PAKNIAT, HAMIDEH. (2019). Analgesic Efficacy of Intravenous Lidocaine Infusion in Cesarean Section under Spinal Anesthesia: A Prospective Randomized Double-Blind Study. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 27(123), 31-37. SID. https://sid.ir/paper/736419/en

Vancouver: Copy

BEIGOM KHEZRI MARZIEH, RAJABI MARYAM, YAGHOOBI SIAMAK, PAKNIAT HAMIDEH. Analgesic Efficacy of Intravenous Lidocaine Infusion in Cesarean Section under Spinal Anesthesia: A Prospective Randomized Double-Blind Study. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2019;27(123):31-37. Available from: https://sid.ir/paper/736419/en

IEEE: Copy

MARZIEH BEIGOM KHEZRI, MARYAM RAJABI, SIAMAK YAGHOOBI, and HAMIDEH PAKNIAT, “Analgesic Efficacy of Intravenous Lidocaine Infusion in Cesarean Section under Spinal Anesthesia: A Prospective Randomized Double-Blind Study,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 27, no. 123, pp. 31–37, 2019, [Online]. Available: https://sid.ir/paper/736419/en

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